The GOAT-Ghrelin System Is Not Essential for Hypoglycemia Prevention during Prolonged Calorie Restriction

OBJECTIVE: Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance. Using a unique set of four different genetic loss-of-function models for the GOAT/ghrelin/growth hormone secretagog...

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Detalles Bibliográficos
Autores principales: Yi, Chun-Xia, Heppner, Kristy M., Kirchner, Henriette, Tong, Jenny, Bielohuby, Maximillian, Gaylinn, Bruce D., Müller, Timo D., Bartley, Erin, Davis, Harold W., Zhao, Yongmei, Joseph, Anupama, Kruthaupt, Traci, Ottaway, Nickki, Kabra, Dhiraj, Habegger, Kirk M., Benoit, Stephen C., Bidlingmaier, Martin, Thorner, Michael O., Perez-Tilve, Diego, Tschöp, Matthias H., Pfluger, Paul T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283719/
https://www.ncbi.nlm.nih.gov/pubmed/22363801
http://dx.doi.org/10.1371/journal.pone.0032100

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