HIV-1 Inhibits Phagocytosis and Inflammatory Cytokine Responses of Human Monocyte-Derived Macrophages to P. falciparum Infected Erythrocytes

HIV-1 infection increases the risk and severity of malaria by poorly defined mechanisms. We investigated the effect of HIV-1(Ba-L) infection of monocyte-derived macrophages (MDM) on phagocytosis of opsonised P. falciparum infected erythrocytes (IE) and subsequent proinflammatory cytokine secretion....

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Autores principales: Ludlow, Louise E., Zhou, Jingling, Tippett, Emma, Cheng, Wan-Jung, Hasang, Wina, Rogerson, Stephen J., Jaworowski, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283736/
https://www.ncbi.nlm.nih.gov/pubmed/22363802
http://dx.doi.org/10.1371/journal.pone.0032102
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author Ludlow, Louise E.
Zhou, Jingling
Tippett, Emma
Cheng, Wan-Jung
Hasang, Wina
Rogerson, Stephen J.
Jaworowski, Anthony
author_facet Ludlow, Louise E.
Zhou, Jingling
Tippett, Emma
Cheng, Wan-Jung
Hasang, Wina
Rogerson, Stephen J.
Jaworowski, Anthony
author_sort Ludlow, Louise E.
collection PubMed
description HIV-1 infection increases the risk and severity of malaria by poorly defined mechanisms. We investigated the effect of HIV-1(Ba-L) infection of monocyte-derived macrophages (MDM) on phagocytosis of opsonised P. falciparum infected erythrocytes (IE) and subsequent proinflammatory cytokine secretion. Compared to mock-infected MDM, HIV-1 infection significantly inhibited phagocytosis of IE (median (IQR) (10 (0–28) versus (34 (27–108); IE internalised/100 MDM; p = 0.001) and decreased secretion of IL-6 (1,116 (352–3,387) versus 1,552 (889–6,331); pg/mL; p = 0.0078) and IL-1β (16 (7–21) versus 33 (27–65); pg/mL; p = 0.0078). Thus inadequate phagocytosis and cytokine production may contribute to impaired control of malaria in HIV-1 infected individuals.
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spelling pubmed-32837362012-02-23 HIV-1 Inhibits Phagocytosis and Inflammatory Cytokine Responses of Human Monocyte-Derived Macrophages to P. falciparum Infected Erythrocytes Ludlow, Louise E. Zhou, Jingling Tippett, Emma Cheng, Wan-Jung Hasang, Wina Rogerson, Stephen J. Jaworowski, Anthony PLoS One Research Article HIV-1 infection increases the risk and severity of malaria by poorly defined mechanisms. We investigated the effect of HIV-1(Ba-L) infection of monocyte-derived macrophages (MDM) on phagocytosis of opsonised P. falciparum infected erythrocytes (IE) and subsequent proinflammatory cytokine secretion. Compared to mock-infected MDM, HIV-1 infection significantly inhibited phagocytosis of IE (median (IQR) (10 (0–28) versus (34 (27–108); IE internalised/100 MDM; p = 0.001) and decreased secretion of IL-6 (1,116 (352–3,387) versus 1,552 (889–6,331); pg/mL; p = 0.0078) and IL-1β (16 (7–21) versus 33 (27–65); pg/mL; p = 0.0078). Thus inadequate phagocytosis and cytokine production may contribute to impaired control of malaria in HIV-1 infected individuals. Public Library of Science 2012-02-21 /pmc/articles/PMC3283736/ /pubmed/22363802 http://dx.doi.org/10.1371/journal.pone.0032102 Text en Ludlow et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ludlow, Louise E.
Zhou, Jingling
Tippett, Emma
Cheng, Wan-Jung
Hasang, Wina
Rogerson, Stephen J.
Jaworowski, Anthony
HIV-1 Inhibits Phagocytosis and Inflammatory Cytokine Responses of Human Monocyte-Derived Macrophages to P. falciparum Infected Erythrocytes
title HIV-1 Inhibits Phagocytosis and Inflammatory Cytokine Responses of Human Monocyte-Derived Macrophages to P. falciparum Infected Erythrocytes
title_full HIV-1 Inhibits Phagocytosis and Inflammatory Cytokine Responses of Human Monocyte-Derived Macrophages to P. falciparum Infected Erythrocytes
title_fullStr HIV-1 Inhibits Phagocytosis and Inflammatory Cytokine Responses of Human Monocyte-Derived Macrophages to P. falciparum Infected Erythrocytes
title_full_unstemmed HIV-1 Inhibits Phagocytosis and Inflammatory Cytokine Responses of Human Monocyte-Derived Macrophages to P. falciparum Infected Erythrocytes
title_short HIV-1 Inhibits Phagocytosis and Inflammatory Cytokine Responses of Human Monocyte-Derived Macrophages to P. falciparum Infected Erythrocytes
title_sort hiv-1 inhibits phagocytosis and inflammatory cytokine responses of human monocyte-derived macrophages to p. falciparum infected erythrocytes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283736/
https://www.ncbi.nlm.nih.gov/pubmed/22363802
http://dx.doi.org/10.1371/journal.pone.0032102
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