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Comparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for isoniazid and ethionamide inactivation

NADH pyrophosphatase (NudC) catalyses the hydrolysis of NAD(H) to AMP and NMN(H) [nicotinamide mononucleotide (reduced form)]. NudC multiple sequence alignment reveals that homologues from most Mycobacterium tuberculosis isolates, but not other mycobacterial species, have a polymorphism at the highl...

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Detalles Bibliográficos
Autores principales:	Wang, Xu-De, Gu, Jing, Wang, Ting, Bi, Li-Jun, Zhang, Zhi-Ping, Cui, Zong-Qiang, Wei, Hong-Ping, Deng, Jiao-Yu, Zhang, Xian-En
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283747/ https://www.ncbi.nlm.nih.gov/pubmed/22026918 http://dx.doi.org/10.1111/j.1365-2958.2011.07892.x

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