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Intravenous Immunoglobulin Treatment in a Child with Resistant Atopic Dermatitis

In a subgroup of patients suffering from atopic dermatitis (AD), treatment is quite difficult even after taking oral immunosuppressants. High-dose intravenous immunoglobulin (IVIG) treatment has been reported to be beneficial for them in a few uncontrolled trials. Herein we report a case of intracta...

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Autores principales: Kwon, Hyuck Hoon, Kim, Kyu Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Dermatological Association; The Korean Society for Investigative Dermatology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283853/
https://www.ncbi.nlm.nih.gov/pubmed/22363158
http://dx.doi.org/10.5021/ad.2012.24.1.66
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author Kwon, Hyuck Hoon
Kim, Kyu Han
author_facet Kwon, Hyuck Hoon
Kim, Kyu Han
author_sort Kwon, Hyuck Hoon
collection PubMed
description In a subgroup of patients suffering from atopic dermatitis (AD), treatment is quite difficult even after taking oral immunosuppressants. High-dose intravenous immunoglobulin (IVIG) treatment has been reported to be beneficial for them in a few uncontrolled trials. Herein we report a case of intractable AD in a 5-year-old girl who had significant clinical improvement after receiving 3 cycles of IVIG treatment (2 g/kg) without notable side effects. Since the first infusion of IVIG, the patient's skin lesions improved steadily and the improvement persisted until the 8-month follow-up. The eczema area and severity index score decreased remarkably, while immunologic parameters did not correlate with clinical improvement. This case suggests that IVIG therapy can be quite effective and safe for children with resistant AD.
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spelling pubmed-32838532012-02-23 Intravenous Immunoglobulin Treatment in a Child with Resistant Atopic Dermatitis Kwon, Hyuck Hoon Kim, Kyu Han Ann Dermatol Case Report In a subgroup of patients suffering from atopic dermatitis (AD), treatment is quite difficult even after taking oral immunosuppressants. High-dose intravenous immunoglobulin (IVIG) treatment has been reported to be beneficial for them in a few uncontrolled trials. Herein we report a case of intractable AD in a 5-year-old girl who had significant clinical improvement after receiving 3 cycles of IVIG treatment (2 g/kg) without notable side effects. Since the first infusion of IVIG, the patient's skin lesions improved steadily and the improvement persisted until the 8-month follow-up. The eczema area and severity index score decreased remarkably, while immunologic parameters did not correlate with clinical improvement. This case suggests that IVIG therapy can be quite effective and safe for children with resistant AD. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2012-02 2012-02-02 /pmc/articles/PMC3283853/ /pubmed/22363158 http://dx.doi.org/10.5021/ad.2012.24.1.66 Text en Copyright © 2012 Korean Dermatological Association; The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kwon, Hyuck Hoon
Kim, Kyu Han
Intravenous Immunoglobulin Treatment in a Child with Resistant Atopic Dermatitis
title Intravenous Immunoglobulin Treatment in a Child with Resistant Atopic Dermatitis
title_full Intravenous Immunoglobulin Treatment in a Child with Resistant Atopic Dermatitis
title_fullStr Intravenous Immunoglobulin Treatment in a Child with Resistant Atopic Dermatitis
title_full_unstemmed Intravenous Immunoglobulin Treatment in a Child with Resistant Atopic Dermatitis
title_short Intravenous Immunoglobulin Treatment in a Child with Resistant Atopic Dermatitis
title_sort intravenous immunoglobulin treatment in a child with resistant atopic dermatitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283853/
https://www.ncbi.nlm.nih.gov/pubmed/22363158
http://dx.doi.org/10.5021/ad.2012.24.1.66
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