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Merkel Cell Carcinoma Concurrent with Bowen's Disease

Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy of the elderly and immunocompromised patients. It is occasionally found coexisting with other diseases, such as squamous cell carcinoma, basal cell carcinoma, actinic keratosis, miscellaneous adnexal tumors, and rarely Bowen dise...

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Autores principales: Park, Hyun Chul, Kang, Ho Song, Park, Kyoung Tae, Oh, Young Ha, Yu, Hee Joon, Kim, Joung Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Dermatological Association; The Korean Society for Investigative Dermatology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283857/
https://www.ncbi.nlm.nih.gov/pubmed/22363161
http://dx.doi.org/10.5021/ad.2012.24.1.77
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author Park, Hyun Chul
Kang, Ho Song
Park, Kyoung Tae
Oh, Young Ha
Yu, Hee Joon
Kim, Joung Soo
author_facet Park, Hyun Chul
Kang, Ho Song
Park, Kyoung Tae
Oh, Young Ha
Yu, Hee Joon
Kim, Joung Soo
author_sort Park, Hyun Chul
collection PubMed
description Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy of the elderly and immunocompromised patients. It is occasionally found coexisting with other diseases, such as squamous cell carcinoma, basal cell carcinoma, actinic keratosis, miscellaneous adnexal tumors, and rarely Bowen disease. A 75-year-old woman presented with a 6-month history of an irregularly shaped erythematous patch on the left mandibular angle. Three months later, a 1.5×1.0 cm sized painless and rapidly growing erythematous nodule developed on the patch. Microscopically, the patch lesion was consistent with that of Bowen disease. The nodular lesion showed a number of small uniform hyperchromatic cells with scanty cytoplasm. It showed dense small-cell like nodular infiltration in the dermis. Immunohistochemical staining for cytokeratin 20 showed a positive result with a dot-like perinuclear pattern. Additionally, the result for thyroid transcription factor-1 was negative, which is positive in small cell neuroendocrine carcinoma. From these findings, we diagnosed this lesion as MCC concurrent with Bowen disease.
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spelling pubmed-32838572012-02-23 Merkel Cell Carcinoma Concurrent with Bowen's Disease Park, Hyun Chul Kang, Ho Song Park, Kyoung Tae Oh, Young Ha Yu, Hee Joon Kim, Joung Soo Ann Dermatol Case Report Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy of the elderly and immunocompromised patients. It is occasionally found coexisting with other diseases, such as squamous cell carcinoma, basal cell carcinoma, actinic keratosis, miscellaneous adnexal tumors, and rarely Bowen disease. A 75-year-old woman presented with a 6-month history of an irregularly shaped erythematous patch on the left mandibular angle. Three months later, a 1.5×1.0 cm sized painless and rapidly growing erythematous nodule developed on the patch. Microscopically, the patch lesion was consistent with that of Bowen disease. The nodular lesion showed a number of small uniform hyperchromatic cells with scanty cytoplasm. It showed dense small-cell like nodular infiltration in the dermis. Immunohistochemical staining for cytokeratin 20 showed a positive result with a dot-like perinuclear pattern. Additionally, the result for thyroid transcription factor-1 was negative, which is positive in small cell neuroendocrine carcinoma. From these findings, we diagnosed this lesion as MCC concurrent with Bowen disease. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2012-02 2012-02-02 /pmc/articles/PMC3283857/ /pubmed/22363161 http://dx.doi.org/10.5021/ad.2012.24.1.77 Text en Copyright © 2012 Korean Dermatological Association; The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Park, Hyun Chul
Kang, Ho Song
Park, Kyoung Tae
Oh, Young Ha
Yu, Hee Joon
Kim, Joung Soo
Merkel Cell Carcinoma Concurrent with Bowen's Disease
title Merkel Cell Carcinoma Concurrent with Bowen's Disease
title_full Merkel Cell Carcinoma Concurrent with Bowen's Disease
title_fullStr Merkel Cell Carcinoma Concurrent with Bowen's Disease
title_full_unstemmed Merkel Cell Carcinoma Concurrent with Bowen's Disease
title_short Merkel Cell Carcinoma Concurrent with Bowen's Disease
title_sort merkel cell carcinoma concurrent with bowen's disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283857/
https://www.ncbi.nlm.nih.gov/pubmed/22363161
http://dx.doi.org/10.5021/ad.2012.24.1.77
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