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Merkel Cell Carcinoma Concurrent with Bowen's Disease
Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy of the elderly and immunocompromised patients. It is occasionally found coexisting with other diseases, such as squamous cell carcinoma, basal cell carcinoma, actinic keratosis, miscellaneous adnexal tumors, and rarely Bowen dise...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Dermatological Association; The Korean Society for Investigative Dermatology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283857/ https://www.ncbi.nlm.nih.gov/pubmed/22363161 http://dx.doi.org/10.5021/ad.2012.24.1.77 |
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author | Park, Hyun Chul Kang, Ho Song Park, Kyoung Tae Oh, Young Ha Yu, Hee Joon Kim, Joung Soo |
author_facet | Park, Hyun Chul Kang, Ho Song Park, Kyoung Tae Oh, Young Ha Yu, Hee Joon Kim, Joung Soo |
author_sort | Park, Hyun Chul |
collection | PubMed |
description | Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy of the elderly and immunocompromised patients. It is occasionally found coexisting with other diseases, such as squamous cell carcinoma, basal cell carcinoma, actinic keratosis, miscellaneous adnexal tumors, and rarely Bowen disease. A 75-year-old woman presented with a 6-month history of an irregularly shaped erythematous patch on the left mandibular angle. Three months later, a 1.5×1.0 cm sized painless and rapidly growing erythematous nodule developed on the patch. Microscopically, the patch lesion was consistent with that of Bowen disease. The nodular lesion showed a number of small uniform hyperchromatic cells with scanty cytoplasm. It showed dense small-cell like nodular infiltration in the dermis. Immunohistochemical staining for cytokeratin 20 showed a positive result with a dot-like perinuclear pattern. Additionally, the result for thyroid transcription factor-1 was negative, which is positive in small cell neuroendocrine carcinoma. From these findings, we diagnosed this lesion as MCC concurrent with Bowen disease. |
format | Online Article Text |
id | pubmed-3283857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Korean Dermatological Association; The Korean Society for Investigative Dermatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-32838572012-02-23 Merkel Cell Carcinoma Concurrent with Bowen's Disease Park, Hyun Chul Kang, Ho Song Park, Kyoung Tae Oh, Young Ha Yu, Hee Joon Kim, Joung Soo Ann Dermatol Case Report Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy of the elderly and immunocompromised patients. It is occasionally found coexisting with other diseases, such as squamous cell carcinoma, basal cell carcinoma, actinic keratosis, miscellaneous adnexal tumors, and rarely Bowen disease. A 75-year-old woman presented with a 6-month history of an irregularly shaped erythematous patch on the left mandibular angle. Three months later, a 1.5×1.0 cm sized painless and rapidly growing erythematous nodule developed on the patch. Microscopically, the patch lesion was consistent with that of Bowen disease. The nodular lesion showed a number of small uniform hyperchromatic cells with scanty cytoplasm. It showed dense small-cell like nodular infiltration in the dermis. Immunohistochemical staining for cytokeratin 20 showed a positive result with a dot-like perinuclear pattern. Additionally, the result for thyroid transcription factor-1 was negative, which is positive in small cell neuroendocrine carcinoma. From these findings, we diagnosed this lesion as MCC concurrent with Bowen disease. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2012-02 2012-02-02 /pmc/articles/PMC3283857/ /pubmed/22363161 http://dx.doi.org/10.5021/ad.2012.24.1.77 Text en Copyright © 2012 Korean Dermatological Association; The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Park, Hyun Chul Kang, Ho Song Park, Kyoung Tae Oh, Young Ha Yu, Hee Joon Kim, Joung Soo Merkel Cell Carcinoma Concurrent with Bowen's Disease |
title | Merkel Cell Carcinoma Concurrent with Bowen's Disease |
title_full | Merkel Cell Carcinoma Concurrent with Bowen's Disease |
title_fullStr | Merkel Cell Carcinoma Concurrent with Bowen's Disease |
title_full_unstemmed | Merkel Cell Carcinoma Concurrent with Bowen's Disease |
title_short | Merkel Cell Carcinoma Concurrent with Bowen's Disease |
title_sort | merkel cell carcinoma concurrent with bowen's disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283857/ https://www.ncbi.nlm.nih.gov/pubmed/22363161 http://dx.doi.org/10.5021/ad.2012.24.1.77 |
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