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Structure-based design, synthesis, molecular docking, and biological activities of 2-(3-benzoylphenyl) propanoic acid derivatives as dual mechanism drugs

PURPOSE: 2-(3-benzoyl phenyl)propanohydroxamic acid (2) and 2-{3-[(hydroxyimino)(phenyl)methyl]phenyl}propanoic acid (3) were synthesized from non-steroidal anti-inflammatory drug, ketoprofen as dual-mechanism drugs. MATERIALS AND METHODS: Structures of the synthesized compounds were established by...

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Detalles Bibliográficos
Autores principales:	Ahmed, Musa A., Azam, Faizul, Rghigh, Abir M., Gbaj, Abdul, Zetrini, Abdulmottaleb E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283955/ https://www.ncbi.nlm.nih.gov/pubmed/22368397 http://dx.doi.org/10.4103/0975-7406.92728

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