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Evaluation of left ventricular dyssynchrony using combined pulsed wave and tissue Doppler imaging

INTRODUCTION: The combination of pulsed wave (PW) and tissue Doppler imaging (TDI) has been proposed as a new method to assess left ventricular (LV) mechanical dyssynchrony (LVMD), but results have not been validated. We investigated the correlation of a combination of PW and TDI with a positive res...

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Autores principales: Shen, Xuedong, Aronow, Wilbert S., Anand, Kishlay, Nair, Chandra K., Holmberg, Mark J., Hee, Tom, Maciejewski, Stephanie, Esterbrooks, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284065/
https://www.ncbi.nlm.nih.gov/pubmed/22371794
http://dx.doi.org/10.5114/aoms.2010.14462
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author Shen, Xuedong
Aronow, Wilbert S.
Anand, Kishlay
Nair, Chandra K.
Holmberg, Mark J.
Hee, Tom
Maciejewski, Stephanie
Esterbrooks, Dennis J.
author_facet Shen, Xuedong
Aronow, Wilbert S.
Anand, Kishlay
Nair, Chandra K.
Holmberg, Mark J.
Hee, Tom
Maciejewski, Stephanie
Esterbrooks, Dennis J.
author_sort Shen, Xuedong
collection PubMed
description INTRODUCTION: The combination of pulsed wave (PW) and tissue Doppler imaging (TDI) has been proposed as a new method to assess left ventricular (LV) mechanical dyssynchrony (LVMD), but results have not been validated. We investigated the correlation of a combination of PW and TDI with a positive response to cardiac resynchronization therapy (CRT). MATERIAL AND METHODS: We studied 108 consecutive patients who received CRT. Patients with atrial fibrillation were excluded. The time difference (T(PW-TDI)) between onset of QRS to the end of LV ejection by PW (T(PW)) and onset of QRS to the end of the systolic wave in LV basal segments with greatest delay by TDI (T(TDI)) was measured before CRT and during short-term and long-term follow-up. RESULTS: The T(PW-TDI) interval before CRT was 74 ±48 ms. Intra-observer variabilities for T(PW) and T(TDI) were 1.5 ±0.24% and 1 ±0.17%. Inter-observer variabilities for T(PW) and T(TDI) were 1 ±0.36% and 1 ±0.64%, respectively. T(PW-TDI) > 50 ms was defined as the cutoff value for diagnosis of LVMD by receiver operating curve (ROC) analysis. During follow-up of 15 ±11 months, the sensitivity and specificity of TP(PW-TDI) to predict a positive response to CRT were 98% and 82%, respectively. The area under the ROC curve was 0.92. There was a significant agreement between LVMD determined by T(PW-TDI) and the positive response to CRT (κ=0.80). CONCLUSIONS: Left vertricular dyssynchrony detected by the method combining PW and TDI demonstrated a high reproducibility, sensitivity, specificity and agreement with a positive response to CRT.
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spelling pubmed-32840652012-02-27 Evaluation of left ventricular dyssynchrony using combined pulsed wave and tissue Doppler imaging Shen, Xuedong Aronow, Wilbert S. Anand, Kishlay Nair, Chandra K. Holmberg, Mark J. Hee, Tom Maciejewski, Stephanie Esterbrooks, Dennis J. Arch Med Sci Clinical Research INTRODUCTION: The combination of pulsed wave (PW) and tissue Doppler imaging (TDI) has been proposed as a new method to assess left ventricular (LV) mechanical dyssynchrony (LVMD), but results have not been validated. We investigated the correlation of a combination of PW and TDI with a positive response to cardiac resynchronization therapy (CRT). MATERIAL AND METHODS: We studied 108 consecutive patients who received CRT. Patients with atrial fibrillation were excluded. The time difference (T(PW-TDI)) between onset of QRS to the end of LV ejection by PW (T(PW)) and onset of QRS to the end of the systolic wave in LV basal segments with greatest delay by TDI (T(TDI)) was measured before CRT and during short-term and long-term follow-up. RESULTS: The T(PW-TDI) interval before CRT was 74 ±48 ms. Intra-observer variabilities for T(PW) and T(TDI) were 1.5 ±0.24% and 1 ±0.17%. Inter-observer variabilities for T(PW) and T(TDI) were 1 ±0.36% and 1 ±0.64%, respectively. T(PW-TDI) > 50 ms was defined as the cutoff value for diagnosis of LVMD by receiver operating curve (ROC) analysis. During follow-up of 15 ±11 months, the sensitivity and specificity of TP(PW-TDI) to predict a positive response to CRT were 98% and 82%, respectively. The area under the ROC curve was 0.92. There was a significant agreement between LVMD determined by T(PW-TDI) and the positive response to CRT (κ=0.80). CONCLUSIONS: Left vertricular dyssynchrony detected by the method combining PW and TDI demonstrated a high reproducibility, sensitivity, specificity and agreement with a positive response to CRT. Termedia Publishing House 2010-09-07 2010-08-30 /pmc/articles/PMC3284065/ /pubmed/22371794 http://dx.doi.org/10.5114/aoms.2010.14462 Text en Copyright © 2010 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Shen, Xuedong
Aronow, Wilbert S.
Anand, Kishlay
Nair, Chandra K.
Holmberg, Mark J.
Hee, Tom
Maciejewski, Stephanie
Esterbrooks, Dennis J.
Evaluation of left ventricular dyssynchrony using combined pulsed wave and tissue Doppler imaging
title Evaluation of left ventricular dyssynchrony using combined pulsed wave and tissue Doppler imaging
title_full Evaluation of left ventricular dyssynchrony using combined pulsed wave and tissue Doppler imaging
title_fullStr Evaluation of left ventricular dyssynchrony using combined pulsed wave and tissue Doppler imaging
title_full_unstemmed Evaluation of left ventricular dyssynchrony using combined pulsed wave and tissue Doppler imaging
title_short Evaluation of left ventricular dyssynchrony using combined pulsed wave and tissue Doppler imaging
title_sort evaluation of left ventricular dyssynchrony using combined pulsed wave and tissue doppler imaging
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284065/
https://www.ncbi.nlm.nih.gov/pubmed/22371794
http://dx.doi.org/10.5114/aoms.2010.14462
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