Cargando…
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis
A proline to serine substitution at position 56 in the gene encoding vesicle-associated membrane protein-associated protein B (VAPB) causes some dominantly inherited familial forms of motor neuron disease including amyotrophic lateral sclerosis (ALS) type-8. VAPB is an integral endoplasmic reticulum...
Autores principales: | De Vos, Kurt J., Mórotz, Gábor M., Stoica, Radu, Tudor, Elizabeth L., Lau, Kwok-Fai, Ackerley, Steven, Warley, Alice, Shaw, Christopher E., Miller, Christopher C.J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284118/ https://www.ncbi.nlm.nih.gov/pubmed/22131369 http://dx.doi.org/10.1093/hmg/ddr559 |
Ejemplares similares
-
The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy
por: Gomez-Suaga, Patricia, et al.
Publicado: (2017) -
ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated
TDP-43
por: Stoica, Radu, et al.
Publicado: (2014) -
Disruption of the VAPB-PTPIP51 ER-mitochondria tethering proteins in post-mortem human amyotrophic lateral sclerosis
por: Hartopp, Naomi, et al.
Publicado: (2022) -
ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations
por: Stoica, Radu, et al.
Publicado: (2016) -
The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity
por: Gómez-Suaga, Patricia, et al.
Publicado: (2019)