Discrete foci containing RNase A are found in nucleoli of HeLa cells aged in culture

We have studied by means of ultrastructural immunocytochemistry the localization of RNase A in nuclei of HeLa cells in control conditions and following cell ageing in culture. We have found that roundish, electron dense foci, which contain a significant amount of RNase A, can be detected within nucl...

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Detalles Bibliográficos
Autores principales: Costanzo, M., Cisterna, B., Zharskaya, O.O., Zatsepina, O.V., Biggiogera, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2011
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284151/
https://www.ncbi.nlm.nih.gov/pubmed/22193295
http://dx.doi.org/10.4081/ejh.2011.e15
Descripción
Sumario:We have studied by means of ultrastructural immunocytochemistry the localization of RNase A in nuclei of HeLa cells in control conditions and following cell ageing in culture. We have found that roundish, electron dense foci, which contain a significant amount of RNase A, can be detected within nucleoli of aged cells. These bodies also contain RNA and lack ribosomal S3 proteins, and may represent either simple storage sites or areas where RNA degradation takes place.

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