Discrete foci containing RNase A are found in nucleoli of HeLa cells aged in culture

We have studied by means of ultrastructural immunocytochemistry the localization of RNase A in nuclei of HeLa cells in control conditions and following cell ageing in culture. We have found that roundish, electron dense foci, which contain a significant amount of RNase A, can be detected within nucl...

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Autores principales: Costanzo, M., Cisterna, B., Zharskaya, O.O., Zatsepina, O.V., Biggiogera, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2011
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284151/
https://www.ncbi.nlm.nih.gov/pubmed/22193295
http://dx.doi.org/10.4081/ejh.2011.e15
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author Costanzo, M.
Cisterna, B.
Zharskaya, O.O.
Zatsepina, O.V.
Biggiogera, M.
author_facet Costanzo, M.
Cisterna, B.
Zharskaya, O.O.
Zatsepina, O.V.
Biggiogera, M.
author_sort Costanzo, M.
collection PubMed
description We have studied by means of ultrastructural immunocytochemistry the localization of RNase A in nuclei of HeLa cells in control conditions and following cell ageing in culture. We have found that roundish, electron dense foci, which contain a significant amount of RNase A, can be detected within nucleoli of aged cells. These bodies also contain RNA and lack ribosomal S3 proteins, and may represent either simple storage sites or areas where RNA degradation takes place.
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spelling pubmed-32841512012-02-23 Discrete foci containing RNase A are found in nucleoli of HeLa cells aged in culture Costanzo, M. Cisterna, B. Zharskaya, O.O. Zatsepina, O.V. Biggiogera, M. Eur J Histochem Letter to the Editor We have studied by means of ultrastructural immunocytochemistry the localization of RNase A in nuclei of HeLa cells in control conditions and following cell ageing in culture. We have found that roundish, electron dense foci, which contain a significant amount of RNase A, can be detected within nucleoli of aged cells. These bodies also contain RNA and lack ribosomal S3 proteins, and may represent either simple storage sites or areas where RNA degradation takes place. PAGEPress Publications 2011-04-13 /pmc/articles/PMC3284151/ /pubmed/22193295 http://dx.doi.org/10.4081/ejh.2011.e15 Text en ©Copyright M. Costanzo et al., 2011 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). Licensee PAGEPress, Italy
spellingShingle Letter to the Editor
Costanzo, M.
Cisterna, B.
Zharskaya, O.O.
Zatsepina, O.V.
Biggiogera, M.
Discrete foci containing RNase A are found in nucleoli of HeLa cells aged in culture
title Discrete foci containing RNase A are found in nucleoli of HeLa cells aged in culture
title_full Discrete foci containing RNase A are found in nucleoli of HeLa cells aged in culture
title_fullStr Discrete foci containing RNase A are found in nucleoli of HeLa cells aged in culture
title_full_unstemmed Discrete foci containing RNase A are found in nucleoli of HeLa cells aged in culture
title_short Discrete foci containing RNase A are found in nucleoli of HeLa cells aged in culture
title_sort discrete foci containing rnase a are found in nucleoli of hela cells aged in culture
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284151/
https://www.ncbi.nlm.nih.gov/pubmed/22193295
http://dx.doi.org/10.4081/ejh.2011.e15
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AT zatsepinaov discretefocicontainingrnaseaarefoundinnucleoliofhelacellsagedinculture
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