Cargando…
From chemical neuroanatomy to an understanding of the olfactory system
The olfactory system of mammals is the appropriate model for studying several aspects of neuronal physiology spanning from the developmental stage to neural network remodelling in the adult brain. Both the morphological and physiological understanding of this system were strongly supported by classi...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284237/ https://www.ncbi.nlm.nih.gov/pubmed/22297441 http://dx.doi.org/10.4081/ejh.2011.e35 |
_version_ | 1782224338150227968 |
---|---|
author | Oboti, L. Peretto, P. De Marchis, S. Fasolo, A. |
author_facet | Oboti, L. Peretto, P. De Marchis, S. Fasolo, A. |
author_sort | Oboti, L. |
collection | PubMed |
description | The olfactory system of mammals is the appropriate model for studying several aspects of neuronal physiology spanning from the developmental stage to neural network remodelling in the adult brain. Both the morphological and physiological understanding of this system were strongly supported by classical histochemistry. It is emblematic the case of the Olfactory Marker Protein (OMP) staining, the first, powerful marker for fully differentiated olfactory receptor neurons and a key tool to investigate the dynamic relations between peripheral sensory epithelia and central relay regions given its presence within olfactory fibers reaching the olfactory bulb (OB). Similarly, the use of thymidine analogues was able to show neurogenesis in an adult mammalian brain far before modern virus labelling and lipophilic tracers based methods. Nowadays, a wealth of new histochemical techniques combining cell and molecular biology approaches is available, giving stance to move from the analysis of the chemically identified circuitries to functional research. The study of adult neurogenesis is indeed one of the best explanatory examples of this statement. After defining the cell types involved and the basic physiology of this phenomenon in the OB plasticity, we can now analyze the role of neurogenesis in well testable behaviours related to socio-chemical communication in rodents. |
format | Online Article Text |
id | pubmed-3284237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | PAGEPress Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-32842372012-02-23 From chemical neuroanatomy to an understanding of the olfactory system Oboti, L. Peretto, P. De Marchis, S. Fasolo, A. Eur J Histochem Review The olfactory system of mammals is the appropriate model for studying several aspects of neuronal physiology spanning from the developmental stage to neural network remodelling in the adult brain. Both the morphological and physiological understanding of this system were strongly supported by classical histochemistry. It is emblematic the case of the Olfactory Marker Protein (OMP) staining, the first, powerful marker for fully differentiated olfactory receptor neurons and a key tool to investigate the dynamic relations between peripheral sensory epithelia and central relay regions given its presence within olfactory fibers reaching the olfactory bulb (OB). Similarly, the use of thymidine analogues was able to show neurogenesis in an adult mammalian brain far before modern virus labelling and lipophilic tracers based methods. Nowadays, a wealth of new histochemical techniques combining cell and molecular biology approaches is available, giving stance to move from the analysis of the chemically identified circuitries to functional research. The study of adult neurogenesis is indeed one of the best explanatory examples of this statement. After defining the cell types involved and the basic physiology of this phenomenon in the OB plasticity, we can now analyze the role of neurogenesis in well testable behaviours related to socio-chemical communication in rodents. PAGEPress Publications 2011-10-19 /pmc/articles/PMC3284237/ /pubmed/22297441 http://dx.doi.org/10.4081/ejh.2011.e35 Text en ©Copyright L. Oboti et al., 2011 This work is licensed under a Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0). Licensee PAGEPress, Italy |
spellingShingle | Review Oboti, L. Peretto, P. De Marchis, S. Fasolo, A. From chemical neuroanatomy to an understanding of the olfactory system |
title | From chemical neuroanatomy to an understanding of the olfactory system |
title_full | From chemical neuroanatomy to an understanding of the olfactory system |
title_fullStr | From chemical neuroanatomy to an understanding of the olfactory system |
title_full_unstemmed | From chemical neuroanatomy to an understanding of the olfactory system |
title_short | From chemical neuroanatomy to an understanding of the olfactory system |
title_sort | from chemical neuroanatomy to an understanding of the olfactory system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284237/ https://www.ncbi.nlm.nih.gov/pubmed/22297441 http://dx.doi.org/10.4081/ejh.2011.e35 |
work_keys_str_mv | AT obotil fromchemicalneuroanatomytoanunderstandingoftheolfactorysystem AT perettop fromchemicalneuroanatomytoanunderstandingoftheolfactorysystem AT demarchiss fromchemicalneuroanatomytoanunderstandingoftheolfactorysystem AT fasoloa fromchemicalneuroanatomytoanunderstandingoftheolfactorysystem |