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A refined, rapid and reproducible high resolution melt (HRM)-based method suitable for quantification of global LINE-1 repetitive element methylation

BACKGROUND: The methylation of DNA is recognized as a key mechanism in the regulation of genomic stability and evidence for its role in the development of cancer is accumulating. LINE-1 methylation status represents a surrogate measure of genome-wide methylation. FINDINGS: Using high resolution melt...

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Detalles Bibliográficos
Autores principales:	Tse, M Yat, Ashbury, Janet E, Zwingerman, Nora, King, Will D, Taylor, Sherry AM, Pang, Stephen C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Technical Note
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284418/ https://www.ncbi.nlm.nih.gov/pubmed/22204640 http://dx.doi.org/10.1186/1756-0500-4-565

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