Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae

Gene inactivation is the cornerstone of functional genetic analysis, but the analysis of essential genes requires conditional inactivation of the gene product. A new study has adapted a simple method for creating conditional alleles to allow large-scale analysis of essential genes in Saccharomyces c...

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Detalles Bibliográficos
Autor principal: Aparicio, Oscar M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC328445/
https://www.ncbi.nlm.nih.gov/pubmed/14519191
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author Aparicio, Oscar M
author_facet Aparicio, Oscar M
author_sort Aparicio, Oscar M
collection PubMed
description Gene inactivation is the cornerstone of functional genetic analysis, but the analysis of essential genes requires conditional inactivation of the gene product. A new study has adapted a simple method for creating conditional alleles to allow large-scale analysis of essential genes in Saccharomyces cerevisiae and has identified a role in DNA replication for a newly identified protein complex.
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spelling pubmed-3284452004-02-05 Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae Aparicio, Oscar M Genome Biol Minireview Gene inactivation is the cornerstone of functional genetic analysis, but the analysis of essential genes requires conditional inactivation of the gene product. A new study has adapted a simple method for creating conditional alleles to allow large-scale analysis of essential genes in Saccharomyces cerevisiae and has identified a role in DNA replication for a newly identified protein complex. BioMed Central 2003 2003-09-24 /pmc/articles/PMC328445/ /pubmed/14519191 Text en Copyright © 2003 BioMed Central Ltd
spellingShingle Minireview
Aparicio, Oscar M
Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae
title Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae
title_full Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae
title_fullStr Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae
title_full_unstemmed Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae
title_short Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae
title_sort tackling an essential problem in functional proteomics of saccharomyces cerevisiae
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC328445/
https://www.ncbi.nlm.nih.gov/pubmed/14519191
work_keys_str_mv AT apariciooscarm tacklinganessentialprobleminfunctionalproteomicsofsaccharomycescerevisiae

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