The Aggregation and Neurotoxicity of TDP-43 and Its ALS-Associated 25 kDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila

Almost all cases of sporadic amyotrophic lateral sclerosis (ALS), and some cases of the familial form, are characterised by the deposition of TDP-43, a member of a family of heteronuclear ribonucleoproteins (hnRNP). Although protein misfolding and deposition is thought to be a causative feature of m...

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Detalles Bibliográficos
Autores principales: Gregory, Jenna M., Barros, Teresa P., Meehan, Sarah, Dobson, Christopher M., Luheshi, Leila M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284513/
https://www.ncbi.nlm.nih.gov/pubmed/22384095
http://dx.doi.org/10.1371/journal.pone.0031899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284513/
https://www.ncbi.nlm.nih.gov/pubmed/22384095
http://dx.doi.org/10.1371/journal.pone.0031899

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