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Left-Shifted Nav Channels in Injured Bilayer: Primary Targets for Neuroprotective Nav Antagonists?

Mechanical, ischemic, and inflammatory injuries to voltage-gated sodium channel (Nav)-rich membranes of axon initial segments and nodes of Ranvier render Nav channels dangerously leaky. By what means? The behavior of recombinant Nav1.6 (Wang et al., 2009) leads us to postulate that, in neuropatholog...

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Detalles Bibliográficos
Autores principales:	Morris, Catherine E., Boucher, Pierre-Alexandre, Joós, Béla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284691/ https://www.ncbi.nlm.nih.gov/pubmed/22375118 http://dx.doi.org/10.3389/fphar.2012.00019

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