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Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states
BACKGROUND: Although pregabalin therapy is beneficial for neuropathic pain (NeP) by targeting the CaVα(2)δ-1 subunit, its site of action is uncertain. Direct targeting of the central nervous system may be beneficial for the avoidance of systemic side effects. RESULTS: We used intranasal, intrathecal...
Autores principales: | Martinez, Jose A, Kasamatsu, Manami, Rosales-Hernandez, Alma, Hanson, Leah R, Frey, William H, Toth, Cory C |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285045/ https://www.ncbi.nlm.nih.gov/pubmed/22236461 http://dx.doi.org/10.1186/1744-8069-8-3 |
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