Clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine

The emergence of induced pluripotent stem cell (iPSC) technology has had a great impact on the field of medicine ever since the ground-breaking discovery in 2006 that overexpression of four specific transcription factors was able to turn back the developmental clock of somatic cells into an embryoni...

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Autores principales: Oh, Yingzi, Wei, Heming, Ma, Dongrui, Sun, Xiaoming, Liew, Reginald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2012
Materias:
Translational Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285138/
https://www.ncbi.nlm.nih.gov/pubmed/22285968
http://dx.doi.org/10.1136/heartjnl-2011-301317
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author Oh, Yingzi
Wei, Heming
Ma, Dongrui
Sun, Xiaoming
Liew, Reginald
author_facet Oh, Yingzi
Wei, Heming
Ma, Dongrui
Sun, Xiaoming
Liew, Reginald
author_sort Oh, Yingzi
collection PubMed
description The emergence of induced pluripotent stem cell (iPSC) technology has had a great impact on the field of medicine ever since the ground-breaking discovery in 2006 that overexpression of four specific transcription factors was able to turn back the developmental clock of somatic cells into an embryonic-like state. The resulting iPSCs carry the developmental potential of human embryonic stem cells (hESC) without the embryo and have been heralded as a powerful tool to study development and disease. This technology has made it possible for the first time for researchers to transform end-differentiated cells from a particular individual into another cell type that remains specific to that individual, paving the way for novel methods of in vitro disease modelling and therapeutic applications. This paper reviews some of the key areas in cardiovascular medicine in which iPSC technology has been applied and discusses the future directions and ongoing challenges ahead in this exciting field.
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spelling pubmed-32851382012-02-28 Clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine Oh, Yingzi Wei, Heming Ma, Dongrui Sun, Xiaoming Liew, Reginald Heart Translational Medicine The emergence of induced pluripotent stem cell (iPSC) technology has had a great impact on the field of medicine ever since the ground-breaking discovery in 2006 that overexpression of four specific transcription factors was able to turn back the developmental clock of somatic cells into an embryonic-like state. The resulting iPSCs carry the developmental potential of human embryonic stem cells (hESC) without the embryo and have been heralded as a powerful tool to study development and disease. This technology has made it possible for the first time for researchers to transform end-differentiated cells from a particular individual into another cell type that remains specific to that individual, paving the way for novel methods of in vitro disease modelling and therapeutic applications. This paper reviews some of the key areas in cardiovascular medicine in which iPSC technology has been applied and discusses the future directions and ongoing challenges ahead in this exciting field. BMJ Group 2012-01-27 2012-03-15 /pmc/articles/PMC3285138/ /pubmed/22285968 http://dx.doi.org/10.1136/heartjnl-2011-301317 Text en © 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Translational Medicine
Oh, Yingzi
Wei, Heming
Ma, Dongrui
Sun, Xiaoming
Liew, Reginald
Clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine
title Clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine
title_full Clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine
title_fullStr Clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine
title_full_unstemmed Clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine
title_short Clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine
title_sort clinical applications of patient-specific induced pluripotent stem cells in cardiovascular medicine
topic Translational Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285138/
https://www.ncbi.nlm.nih.gov/pubmed/22285968
http://dx.doi.org/10.1136/heartjnl-2011-301317
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