Cargando…

Rational Approaches to Improving Selectivity in Drug Design

Detalles Bibliográficos
Autores principales:	Huggins, David J., Sherman, Woody, Tidor, Bruce
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2012
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285144/ https://www.ncbi.nlm.nih.gov/pubmed/22239221 http://dx.doi.org/10.1021/jm2010332

Ejemplares similares

Stimulus Design for Model Selection and Validation in Cell Signaling
por: Apgar, Joshua F, et al.
Publicado: (2008)

Molecular mechanisms and design principles for promiscuous inhibitors to avoid drug resistance: Lessons learned from HIV‐1 protease inhibition
por: Shen, Yang, et al.
Publicado: (2015)

Rational drug design
por: Truhlar, Donald, et al.
Publicado: (1999)

Combined Model of Intrinsic and Extrinsic Variability for Computational Network Design with Application to Synthetic Biology
por: Toni, Tina, et al.
Publicado: (2013)

Convergence in parameters and predictions using computational experimental design
por: Hagen, David R., et al.
Publicado: (2013)

Rational Design of Improved Pharmabiotics
por: Sleator, Roy D., et al.
Publicado: (2009)

Computational Methods Applied to Rational Drug Design
por: Ramírez, David
Publicado: (2016)

Mutagenic Activation of Glutathione Peroxidase-4: Approaches toward Rational Design of Allosteric Drugs
por: Ma, Chunyue, et al.
Publicado: (2022)

A Mathematical Model for the Rational Design of Chimeric Ligands in Selective Drug Therapies
por: Doldán-Martelli, V, et al.
Publicado: (2013)

Cocrystals by Design: A Rational Coformer Selection Approach for Tackling the API Problems
por: Singh, Maan, et al.
Publicado: (2023)

GPCR Conformations: Implications for Rational Drug Design
por: Parrill, Abby L., et al.
Publicado: (2010)

Rationally Designed DNA Nanostructures for Drug Delivery
por: Xu, Fan, et al.
Publicado: (2020)

Rationality over fashion and hype in drug design
por: Medina-Franco, José L., et al.
Publicado: (2021)

Novel approaches for the rational design of PROTAC linkers
por: Zagidullin, Almaz, et al.
Publicado: (2020)

Overcoming mutation-based resistance to antiandrogens with rational drug design
por: Balbas, Minna D, et al.
Publicado: (2013)

A Rationalized Approach to Thermionic RF Gun Design
por: Beczek, K J, et al.
Publicado: (2001)

Rational approach to drug discovery for human schistosomiasis
por: LoVerde, Philip T., et al.
Publicado: (2021)

TRPV1: A Target for Rational Drug Design
por: Carnevale, Vincenzo, et al.
Publicado: (2016)

On the Rational Drug Design for Hypertension through NMR Spectroscopy
por: Chontzopoulou, Eleni, et al.
Publicado: (2020)

Rational design of yolk–shell nanostructures for drug delivery
por: Mohammadi Ziarani, Ghodsi, et al.
Publicado: (2020)

The role of multiscale computational approaches for rational design of conventional and nanoparticle oral drug delivery systems
por: Haddish-Berhane, Nahor, et al.
Publicado: (2007)

Computational approaches for rational design of proteins with novel functionalities
por: Tiwari, Manish Kumar, et al.
Publicado: (2012)

Computational Approaches to the Rational Design of Tubulin-Targeting Agents
por: Pérez-Peña, Helena, et al.
Publicado: (2023)

Rationally designed mineralization for selective recovery of the rare earth elements
por: Hatanaka, Takaaki, et al.
Publicado: (2017)

A rational approach to selective pharmacophore designing: an innovative strategy for specific recognition of Gsk3β
por: Pradeep, H., et al.
Publicado: (2012)

Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design
por: Leighow, Scott M., et al.
Publicado: (2020)

Novel approaches for the rapid development of rationally designed arbovirus vaccines
por: van Bree, Joyce W.M., et al.
Publicado: (2023)

Rational Design of P450 aMOx for Improving Anti-Markovnikov Selectivity Based on the “Butterfly” Model
por: Pan, Yue, et al.
Publicado: (2022)

Cancer Drug Delivery: Considerations in the Rational Design of Nanosized Bioconjugates
por: Kobayashi, Hisataka, et al.
Publicado: (2014)

Molecular targets for the rational design of drugs to inhibit SARS coronavirus
por: Brockway, Sarah M., et al.
Publicado: (2004)

Editorial: Rational drug design of metal complexes for cancer therapy
por: Morais, Tânia S., et al.
Publicado: (2022)

Covalent inhibitors: a rational approach to drug discovery
por: Sutanto, Fandi, et al.
Publicado: (2020)

Binding of small molecules at interface of protein–protein complex – A newer approach to rational drug design
por: Gurung, A.B., et al.
Publicado: (2017)

Molecular Basis of Differential Selectivity of Cyclobutyl-Substituted Imidazole Inhibitors against CDKs: Insights for Rational Drug Design
por: Rath, Soumya Lipsa, et al.
Publicado: (2013)

The rational design of vaccines
por: Bramwell, Vincent W., et al.
Publicado: (2005)

Comprehensive Approach to Simulating Large Scale Conformational Changes in Biological Systems Utilizing a Path Collective Variable and New Barrier Restraint
por: Kolossváry, István, et al.
Publicado: (2023)

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
por: Tang, Qi, et al.
Publicado: (2023)

In silico approach to designing rational metagenomic libraries for functional studies
por: Kusnezowa, Anna, et al.
Publicado: (2017)

Computational Approach for Rational Design of Fusion Uricase with PAS Sequences
por: Najjari, Abbas, et al.
Publicado: (2020)

A rationally designed JAZ subtype-selective agonist of jasmonate perception
por: Takaoka, Yousuke, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ag3gl816nadmb54vc4upopdkbj