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Different Requirements for Proteolytic Processing of Bone Morphogenetic Protein 5/6/7/8 Ligands in Drosophila melanogaster

Bone morphogenetic proteins (BMPs) are synthesized as proproteins that undergo proteolytic processing by furin/subtilisin proprotein convertases to release the active ligand. Here we study processing of BMP5/6/7/8 proteins, including the Drosophila orthologs Glass Bottom Boat (Gbb) and Screw (Scw) a...

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Detalles Bibliográficos
Autores principales:	Fritsch, Cornelia, Sawala, Annick, Harris, Robin, Maartens, Aidan, Sutcliffe, Catherine, Ashe, Hilary L., Ray, Robert P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285362/ https://www.ncbi.nlm.nih.gov/pubmed/22199351 http://dx.doi.org/10.1074/jbc.M111.316745

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