Cargando…

Complete subunit architecture of the proteasome regulatory particle

The proteasome is the major ATP-dependent protease in eukaryotic cells, but limited structural information strongly restricts a mechanistic understanding of its activities. The proteasome regulatory particle, consisting of the lid and base subcomplexes, recognizes and processes poly-ubiquitinated su...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lander, Gabriel C., Estrin, Eric, Matyskiela, Mary E., Bashore, Charlene, Nogales, Eva, Martin, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285539/ https://www.ncbi.nlm.nih.gov/pubmed/22237024 http://dx.doi.org/10.1038/nature10774

Ejemplares similares

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome
por: Bashore, Charlene, et al.
Publicado: (2015)

Conformational switching of the 26S proteasome enables substrate degradation
por: Matyskiela, Mary E., et al.
Publicado: (2013)

Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation
por: Greene, Eric R, et al.
Publicado: (2019)

Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase
por: Beckwith, Robyn, et al.
Publicado: (2013)

An asymmetric interface between the regulatory particle and core particle of the proteasome
por: Tian, Geng, et al.
Publicado: (2011)

Molecular architecture of human polycomb repressive complex 2
por: Ciferri, Claudio, et al.
Publicado: (2012)

Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association
por: Wani, Prashant S., et al.
Publicado: (2015)

Assembly checkpoint of the proteasome regulatory particle is activated by coordinated actions of proteasomal ATPase chaperones
por: Nahar, Asrafun, et al.
Publicado: (2022)

The central unit within the 19S regulatory particle of the proteasome
por: Rosenzweig, Rina, et al.
Publicado: (2008)

Chaperone-mediated pathway of proteasome regulatory particle assembly
por: Roelofs, Jeroen, et al.
Publicado: (2009)

Allostery Modulates Interactions between Proteasome Core Particles and Regulatory Particles
por: Coffino, Philip, et al.
Publicado: (2022)

A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly
por: Tomko, Robert J., et al.
Publicado: (2015)

The Regulatory Complex of Drosophila melanogaster 26s Proteasomes: Subunit Composition and Localization of a Deubiquitylating Enzyme
por: Hölzl, Harald, et al.
Publicado: (2000)

The 26S Proteasome Regulatory Subunit GmPSMD Promotes Resistance to Phytophthora sojae in Soybean
por: Liu, Tengfei, et al.
Publicado: (2021)

Depleting the 19S proteasome regulatory PSMD1 subunit as a cancer therapy strategy
por: Adler, Julia, et al.
Publicado: (2023)

Assembly chaperone Nas6 selectively destabilizes 26S proteasomes with defective regulatory particle-core particle interfaces
por: Warnock, Jennifer L., et al.
Publicado: (2023)

Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates
por: Sandu, Cristinel, et al.
Publicado: (2015)

Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex
por: Wang, Yanxing, et al.
Publicado: (2018)

Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles
por: Waite, Kenrick A., et al.
Publicado: (2016)

Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits
por: Acosta-Alvear, Diego, et al.
Publicado: (2015)

Proteins Directly Interacting with Mammalian 20S Proteasomal Subunits and Ubiquitin-Independent Proteasomal Degradation
por: Sánchez-Lanzas, Raúl, et al.
Publicado: (2014)

Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition
por: Dambacher, Corey M, et al.
Publicado: (2016)

Cooperativity in Proteasome Core Particle Maturation
por: Suppahia, Anjana, et al.
Publicado: (2020)

N-Terminal Coiled-Coil Structure of ATPase Subunits of 26S Proteasome Is Crucial for Proteasome Function
por: Inobe, Tomonao, et al.
Publicado: (2015)

Increased 26S proteasome non-ATPase regulatory subunit 1 in the aqueous humor of patients with age-related macular degeneration
por: Lee, Hyungwoo, et al.
Publicado: (2014)

Modification of Cul1 regulates its association with proteasomal subunits
por: Bloom, Joanna, et al.
Publicado: (2006)

Expression of catalytic proteasome subunits in the gut of patients with Crohn’s disease
por: Visekruna, Alexander, et al.
Publicado: (2009)

A novel role of proteasomal β1 subunit in tumorigenesis
por: Yuan, Fuqiang, et al.
Publicado: (2013)

Proteasome subunit α1 overexpression preferentially drives canonical proteasome biogenesis and enhances stress tolerance in yeast
por: Howell, Lauren A., et al.
Publicado: (2019)

The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System
por: Fuchs, Adrian C.D., et al.
Publicado: (2017)

Targeted degradation via direct 26S proteasome recruitment
por: Bashore, Charlene, et al.
Publicado: (2022)

26S Proteasome Non-ATPase Regulatory Subunits 1 (PSMD1) and 3 (PSMD3) as Putative Targets for Cancer Prognosis and Therapy
por: Rubio, Andres J., et al.
Publicado: (2021)

Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma
Publicado: (1996)

The Protein Quality Control Machinery Regulates Its Misassembled Proteasome Subunits
por: Peters, Lee Zeev, et al.
Publicado: (2015)

Bortezomib-resistance is associated with increased levels of proteasome subunits and apoptosis-avoidance
por: Wu, Yi-Xin, et al.
Publicado: (2016)

Structure‐Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits
por: Maurits, Elmer, et al.
Publicado: (2020)

Conserved Mitotic Phosphorylation of a Proteasome Subunit Regulates Cell Proliferation
por: Duan, Jinyuan, et al.
Publicado: (2021)

Deubiquitination of proteasome subunits by OTULIN regulates type I IFN production
por: Tao, Panfeng, et al.
Publicado: (2021)

Proteasomal subunit depletions differentially affect germline integrity in C. elegans
por: Fernando, Lourds Michelle, et al.
Publicado: (2022)

Understanding the separation of timescales in bacterial proteasome core particle assembly
por: Itagi, Pushpa, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_brqdsucju4b8rlr7vpmgrji2sq