Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease

Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the antimicrobial peptides DEFA5 (HD-5) and DEFA6 (HD-6). Both of these α-defensins are exclusively produced in Paneth cells (PCs) at small intestinal crypt bases. Different ileal...

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Detalles Bibliográficos
Autores principales: Koslowski, Maureen J., Teltschik, Zora, Beisner, Julia, Schaeffeler, Elke, Wang, Guoxing, Kübler, Irmgard, Gersemann, Michael, Cooney, Rachel, Jewell, Derek, Reinisch, Walter, Vermeire, Séverine, Rutgeerts, Paul, Schwab, Matthias, Stange, Eduard F., Wehkamp, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285585/
https://www.ncbi.nlm.nih.gov/pubmed/22393312
http://dx.doi.org/10.1371/journal.pgen.1002523

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