The Invasive Capacity of HPV Transformed Cells Requires the hDlg-Dependent Enhancement of SGEF/RhoG Activity

A major target of the HPV E6 oncoprotein is the human Discs Large (hDlg) tumour suppressor, although how this interaction contributes to HPV-induced malignancy is still unclear. Using a proteomic approach we show that a strong interacting partner of hDlg is the RhoG-specific guanine nucleotide excha...

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Detalles Bibliográficos
Autores principales: Krishna Subbaiah, Vanitha, Massimi, Paola, Boon, Siaw Shi, Myers, Michael P., Sharek, Lisa, Garcia-Mata, Rafael, Banks, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285591/
https://www.ncbi.nlm.nih.gov/pubmed/22383878
http://dx.doi.org/10.1371/journal.ppat.1002543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285591/
https://www.ncbi.nlm.nih.gov/pubmed/22383878
http://dx.doi.org/10.1371/journal.ppat.1002543

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