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The Invasive Capacity of HPV Transformed Cells Requires the hDlg-Dependent Enhancement of SGEF/RhoG Activity
A major target of the HPV E6 oncoprotein is the human Discs Large (hDlg) tumour suppressor, although how this interaction contributes to HPV-induced malignancy is still unclear. Using a proteomic approach we show that a strong interacting partner of hDlg is the RhoG-specific guanine nucleotide excha...
Autores principales: | Krishna Subbaiah, Vanitha, Massimi, Paola, Boon, Siaw Shi, Myers, Michael P., Sharek, Lisa, Garcia-Mata, Rafael, Banks, Lawrence |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285591/ https://www.ncbi.nlm.nih.gov/pubmed/22383878 http://dx.doi.org/10.1371/journal.ppat.1002543 |
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