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Early Priming Minimizes the Age-Related Immune Compromise of CD8(+) T Cell Diversity and Function

The elderly are particularly susceptible to influenza A virus infections, with increased occurrence, disease severity and reduced vaccine efficacy attributed to declining immunity. Experimentally, the age-dependent decline in influenza-specific CD8(+) T cell responsiveness reflects both functional c...

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Detalles Bibliográficos
Autores principales:	Valkenburg, Sophie A., Venturi, Vanessa, Dang, Thurston H. Y., Bird, Nicola L., Doherty, Peter C., Turner, Stephen J., Davenport, Miles P., Kedzierska, Katherine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285595/ https://www.ncbi.nlm.nih.gov/pubmed/22383879 http://dx.doi.org/10.1371/journal.ppat.1002544

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