A P-loop Mutation in Gα Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis

Heterotrimeric G-proteins are molecular switches integral to a panoply of different physiological responses that many organisms make to environmental cues. The switch from inactive to active Gαβγ heterotrimer relies on nucleotide cycling by the Gα subunit: exchange of GTP for GDP activates Gα, where...

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Detalles Bibliográficos
Autores principales: Bosch, Dustin E., Willard, Francis S., Ramanujam, Ravikrishna, Kimple, Adam J., Willard, Melinda D., Naqvi, Naweed I., Siderovski, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285607/
https://www.ncbi.nlm.nih.gov/pubmed/22383884
http://dx.doi.org/10.1371/journal.ppat.1002553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285607/
https://www.ncbi.nlm.nih.gov/pubmed/22383884
http://dx.doi.org/10.1371/journal.ppat.1002553

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