Ascl2 Knockdown Results in Tumor Growth Arrest by miRNA-302b-Related Inhibition of Colon Cancer Progenitor Cells

BACKGROUND: Achaete scute-like 2 (Ascl2), a basic helix-loop-helix (bHLH) transcription factor, controls the fate of intestinal stem cells. However, the role of Ascl2 in colon cancer progenitor cells remains unknown. The cell line HT-29 (47.5–95% of CD133(+) population) and LS174T (0.45% of CD133(+)...

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Detalles Bibliográficos
Autores principales: Zhu, Rong, Yang, Yongtao, Tian, Yin, Bai, Jianying, Zhang, Xin, Li, Xiaohuan, Peng, Zhihong, He, Yonghong, Chen, Lei, Pan, Qiong, Fang, Dianchun, Chen, Wensheng, Qian, Chen, Bian, Xiuwu, Wang, Rongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285660/
https://www.ncbi.nlm.nih.gov/pubmed/22384170
http://dx.doi.org/10.1371/journal.pone.0032170

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