Allelic Origin of Protease-Sensitive and Protease-Resistant Prion Protein Isoforms in Gerstmann-Sträussler-Scheinker Disease with the P102L Mutation

Gerstmann-Sträussler-Scheinker (GSS) disease is a dominantly inherited prion disease associated with point mutations in the Prion Protein gene. The most frequent mutation associated with GSS involves a proline-to-leucine substitution at residue 102 of the prion protein, and is characterized by marke...

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Detalles Bibliográficos
Autores principales: Monaco, Salvatore, Fiorini, Michele, Farinazzo, Alessia, Ferrari, Sergio, Gelati, Matteo, Piccardo, Pedro, Zanusso, Gianluigi, Ghetti, Bernardino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285667/
https://www.ncbi.nlm.nih.gov/pubmed/22384235
http://dx.doi.org/10.1371/journal.pone.0032382

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