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Tumor microenvironment: becoming sick of Myc
Several years ago, we described Myc as “the oncogene from hell”, since evidence had just emerged that Myc, aside from being responsible for cell-cycle progression and tumor expansion, was also able to induce genomic instability in culture, wreaking havoc in tumor cells and accelerating tumor progres...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SP Birkhäuser Verlag Basel
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285755/ https://www.ncbi.nlm.nih.gov/pubmed/22033838 http://dx.doi.org/10.1007/s00018-011-0860-x |
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author | Whitfield, Jonathan R. Soucek, Laura |
author_facet | Whitfield, Jonathan R. Soucek, Laura |
author_sort | Whitfield, Jonathan R. |
collection | PubMed |
description | Several years ago, we described Myc as “the oncogene from hell”, since evidence had just emerged that Myc, aside from being responsible for cell-cycle progression and tumor expansion, was also able to induce genomic instability in culture, wreaking havoc in tumor cells and accelerating tumor progression (Soucek and Evan, Cancer Cell 1:406–408, 2002; Vafa et al., Mol Cell 9:1031–1044, 2002). In this review, we discuss recent publications that expand Myc’s evil armory to include coordination of the crosstalk between tumor and microenvironment. Indeed, endogenous Myc, acting as a client for upstream oncogenic lesions, instructs the tumor stroma, engages a complex inflammatory response and induces angiogenesis, thus allowing the tumor to thrive. This is highly topical in light of the fact that Hanahan and Weinberg have recently redefined the hallmarks of cancer and pointed out that genomic instability and inflammation are essential for both their acquisition and development (Hanahan and Weinberg, Cell 144:646–674, 2011). Myc, it seems, is behind it all. |
format | Online Article Text |
id | pubmed-3285755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SP Birkhäuser Verlag Basel |
record_format | MEDLINE/PubMed |
spelling | pubmed-32857552012-03-08 Tumor microenvironment: becoming sick of Myc Whitfield, Jonathan R. Soucek, Laura Cell Mol Life Sci Review Several years ago, we described Myc as “the oncogene from hell”, since evidence had just emerged that Myc, aside from being responsible for cell-cycle progression and tumor expansion, was also able to induce genomic instability in culture, wreaking havoc in tumor cells and accelerating tumor progression (Soucek and Evan, Cancer Cell 1:406–408, 2002; Vafa et al., Mol Cell 9:1031–1044, 2002). In this review, we discuss recent publications that expand Myc’s evil armory to include coordination of the crosstalk between tumor and microenvironment. Indeed, endogenous Myc, acting as a client for upstream oncogenic lesions, instructs the tumor stroma, engages a complex inflammatory response and induces angiogenesis, thus allowing the tumor to thrive. This is highly topical in light of the fact that Hanahan and Weinberg have recently redefined the hallmarks of cancer and pointed out that genomic instability and inflammation are essential for both their acquisition and development (Hanahan and Weinberg, Cell 144:646–674, 2011). Myc, it seems, is behind it all. SP Birkhäuser Verlag Basel 2011-10-28 2012 /pmc/articles/PMC3285755/ /pubmed/22033838 http://dx.doi.org/10.1007/s00018-011-0860-x Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Whitfield, Jonathan R. Soucek, Laura Tumor microenvironment: becoming sick of Myc |
title | Tumor microenvironment: becoming sick of Myc |
title_full | Tumor microenvironment: becoming sick of Myc |
title_fullStr | Tumor microenvironment: becoming sick of Myc |
title_full_unstemmed | Tumor microenvironment: becoming sick of Myc |
title_short | Tumor microenvironment: becoming sick of Myc |
title_sort | tumor microenvironment: becoming sick of myc |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285755/ https://www.ncbi.nlm.nih.gov/pubmed/22033838 http://dx.doi.org/10.1007/s00018-011-0860-x |
work_keys_str_mv | AT whitfieldjonathanr tumormicroenvironmentbecomingsickofmyc AT souceklaura tumormicroenvironmentbecomingsickofmyc |