Cargando…
LIF-Dependent Signaling: New Pieces in the Lego
LIF, a member of the IL6 family of cytokine, displays pleiotropic effects on various cell types and organs. Its critical role in stem cell models (e.g.: murine ES, human mesenchymal cells) and its essential non redundant function during the implantation process of embryos, in eutherian mammals, put...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Humana Press Inc
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285761/ https://www.ncbi.nlm.nih.gov/pubmed/21537995 http://dx.doi.org/10.1007/s12015-011-9261-7 |
_version_ | 1782224522452140032 |
---|---|
author | Mathieu, Marie-Emmanuelle Saucourt, Claire Mournetas, Virginie Gauthereau, Xavier Thézé, Nadine Praloran, Vincent Thiébaud, Pierre Bœuf, Hélène |
author_facet | Mathieu, Marie-Emmanuelle Saucourt, Claire Mournetas, Virginie Gauthereau, Xavier Thézé, Nadine Praloran, Vincent Thiébaud, Pierre Bœuf, Hélène |
author_sort | Mathieu, Marie-Emmanuelle |
collection | PubMed |
description | LIF, a member of the IL6 family of cytokine, displays pleiotropic effects on various cell types and organs. Its critical role in stem cell models (e.g.: murine ES, human mesenchymal cells) and its essential non redundant function during the implantation process of embryos, in eutherian mammals, put this cytokine at the core of many studies aiming to understand its mechanisms of action, which could benefit to medical applications. In addition, its conservation upon evolution raised the challenging question concerning the function of LIF in species in which there is no implantation. We present the recent knowledge about the established and potential functions of LIF in different stem cell models, (embryonic, hematopoietic, mesenchymal, muscle, neural stem cells and iPSC). We will also discuss EVO-DEVO aspects of this multifaceted cytokine. |
format | Online Article Text |
id | pubmed-3285761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Humana Press Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-32857612012-03-08 LIF-Dependent Signaling: New Pieces in the Lego Mathieu, Marie-Emmanuelle Saucourt, Claire Mournetas, Virginie Gauthereau, Xavier Thézé, Nadine Praloran, Vincent Thiébaud, Pierre Bœuf, Hélène Stem Cell Rev Article LIF, a member of the IL6 family of cytokine, displays pleiotropic effects on various cell types and organs. Its critical role in stem cell models (e.g.: murine ES, human mesenchymal cells) and its essential non redundant function during the implantation process of embryos, in eutherian mammals, put this cytokine at the core of many studies aiming to understand its mechanisms of action, which could benefit to medical applications. In addition, its conservation upon evolution raised the challenging question concerning the function of LIF in species in which there is no implantation. We present the recent knowledge about the established and potential functions of LIF in different stem cell models, (embryonic, hematopoietic, mesenchymal, muscle, neural stem cells and iPSC). We will also discuss EVO-DEVO aspects of this multifaceted cytokine. Humana Press Inc 2011-05-03 2012 /pmc/articles/PMC3285761/ /pubmed/21537995 http://dx.doi.org/10.1007/s12015-011-9261-7 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article Mathieu, Marie-Emmanuelle Saucourt, Claire Mournetas, Virginie Gauthereau, Xavier Thézé, Nadine Praloran, Vincent Thiébaud, Pierre Bœuf, Hélène LIF-Dependent Signaling: New Pieces in the Lego |
title | LIF-Dependent Signaling: New Pieces in the Lego |
title_full | LIF-Dependent Signaling: New Pieces in the Lego |
title_fullStr | LIF-Dependent Signaling: New Pieces in the Lego |
title_full_unstemmed | LIF-Dependent Signaling: New Pieces in the Lego |
title_short | LIF-Dependent Signaling: New Pieces in the Lego |
title_sort | lif-dependent signaling: new pieces in the lego |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285761/ https://www.ncbi.nlm.nih.gov/pubmed/21537995 http://dx.doi.org/10.1007/s12015-011-9261-7 |
work_keys_str_mv | AT mathieumarieemmanuelle lifdependentsignalingnewpiecesinthelego AT saucourtclaire lifdependentsignalingnewpiecesinthelego AT mournetasvirginie lifdependentsignalingnewpiecesinthelego AT gauthereauxavier lifdependentsignalingnewpiecesinthelego AT thezenadine lifdependentsignalingnewpiecesinthelego AT praloranvincent lifdependentsignalingnewpiecesinthelego AT thiebaudpierre lifdependentsignalingnewpiecesinthelego AT bœufhelene lifdependentsignalingnewpiecesinthelego |