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Primitive Duplicate Hox Clusters in the European Eel's Genome
The enigmatic life cycle and elongated body of the European eel (Anguilla anguilla L., 1758) have long motivated scientific enquiry. Recently, eel research has gained in urgency, as the population has dwindled to the point of critical endangerment. We have assembled a draft genome in order to facili...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286462/ https://www.ncbi.nlm.nih.gov/pubmed/22384188 http://dx.doi.org/10.1371/journal.pone.0032231 |
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author | Henkel, Christiaan V. Burgerhout, Erik de Wijze, Daniëlle L. Dirks, Ron P. Minegishi, Yuki Jansen, Hans J. Spaink, Herman P. Dufour, Sylvie Weltzien, Finn-Arne Tsukamoto, Katsumi van den Thillart, Guido E. E. J. M. |
author_facet | Henkel, Christiaan V. Burgerhout, Erik de Wijze, Daniëlle L. Dirks, Ron P. Minegishi, Yuki Jansen, Hans J. Spaink, Herman P. Dufour, Sylvie Weltzien, Finn-Arne Tsukamoto, Katsumi van den Thillart, Guido E. E. J. M. |
author_sort | Henkel, Christiaan V. |
collection | PubMed |
description | The enigmatic life cycle and elongated body of the European eel (Anguilla anguilla L., 1758) have long motivated scientific enquiry. Recently, eel research has gained in urgency, as the population has dwindled to the point of critical endangerment. We have assembled a draft genome in order to facilitate advances in all provinces of eel biology. Here, we use the genome to investigate the eel's complement of the Hox developmental transcription factors. We show that unlike any other teleost fish, the eel retains fully populated, duplicate Hox clusters, which originated at the teleost-specific genome duplication. Using mRNA-sequencing and in situ hybridizations, we demonstrate that all copies are expressed in early embryos. Theories of vertebrate evolution predict that the retention of functional, duplicate Hox genes can give rise to additional developmental complexity, which is not immediately apparent in the adult. However, the key morphological innovation elsewhere in the eel's life history coincides with the evolutionary origin of its Hox repertoire. |
format | Online Article Text |
id | pubmed-3286462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-32864622012-03-01 Primitive Duplicate Hox Clusters in the European Eel's Genome Henkel, Christiaan V. Burgerhout, Erik de Wijze, Daniëlle L. Dirks, Ron P. Minegishi, Yuki Jansen, Hans J. Spaink, Herman P. Dufour, Sylvie Weltzien, Finn-Arne Tsukamoto, Katsumi van den Thillart, Guido E. E. J. M. PLoS One Research Article The enigmatic life cycle and elongated body of the European eel (Anguilla anguilla L., 1758) have long motivated scientific enquiry. Recently, eel research has gained in urgency, as the population has dwindled to the point of critical endangerment. We have assembled a draft genome in order to facilitate advances in all provinces of eel biology. Here, we use the genome to investigate the eel's complement of the Hox developmental transcription factors. We show that unlike any other teleost fish, the eel retains fully populated, duplicate Hox clusters, which originated at the teleost-specific genome duplication. Using mRNA-sequencing and in situ hybridizations, we demonstrate that all copies are expressed in early embryos. Theories of vertebrate evolution predict that the retention of functional, duplicate Hox genes can give rise to additional developmental complexity, which is not immediately apparent in the adult. However, the key morphological innovation elsewhere in the eel's life history coincides with the evolutionary origin of its Hox repertoire. Public Library of Science 2012-02-24 /pmc/articles/PMC3286462/ /pubmed/22384188 http://dx.doi.org/10.1371/journal.pone.0032231 Text en Henkel et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Henkel, Christiaan V. Burgerhout, Erik de Wijze, Daniëlle L. Dirks, Ron P. Minegishi, Yuki Jansen, Hans J. Spaink, Herman P. Dufour, Sylvie Weltzien, Finn-Arne Tsukamoto, Katsumi van den Thillart, Guido E. E. J. M. Primitive Duplicate Hox Clusters in the European Eel's Genome |
title | Primitive Duplicate Hox Clusters in the European Eel's Genome |
title_full | Primitive Duplicate Hox Clusters in the European Eel's Genome |
title_fullStr | Primitive Duplicate Hox Clusters in the European Eel's Genome |
title_full_unstemmed | Primitive Duplicate Hox Clusters in the European Eel's Genome |
title_short | Primitive Duplicate Hox Clusters in the European Eel's Genome |
title_sort | primitive duplicate hox clusters in the european eel's genome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286462/ https://www.ncbi.nlm.nih.gov/pubmed/22384188 http://dx.doi.org/10.1371/journal.pone.0032231 |
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