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The Effect of Prolonged Physical Activity Performed during Extreme Caloric Deprivation on Cardiac Function
BACKGROUND: Endurance exercise may induce transient cardiac dysfunction. Data regarding the effect of caloric restriction on cardiac function is limited. We studied the effect of physical activity performed during extreme caloric deprivation on cardiac function. METHODS: Thirty-nine healthy male sol...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286482/ https://www.ncbi.nlm.nih.gov/pubmed/22384007 http://dx.doi.org/10.1371/journal.pone.0031266 |
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author | Planer, David Leibowitz, David Hadid, Amir Erlich, Tomer Sharon, Nir Paltiel, Ora Jacoby, Elad Lotan, Chaim Moran, Daniel S. |
author_facet | Planer, David Leibowitz, David Hadid, Amir Erlich, Tomer Sharon, Nir Paltiel, Ora Jacoby, Elad Lotan, Chaim Moran, Daniel S. |
author_sort | Planer, David |
collection | PubMed |
description | BACKGROUND: Endurance exercise may induce transient cardiac dysfunction. Data regarding the effect of caloric restriction on cardiac function is limited. We studied the effect of physical activity performed during extreme caloric deprivation on cardiac function. METHODS: Thirty-nine healthy male soldiers (mean age 20±0.3 years) were studied during a field training exercise lasted 85–103 hours, with negligible food intake and unlimited water supply. Anthropometric measurements, echocardiographic examinations and blood and urine tests were performed before and after the training exercise. RESULTS: Baseline VO(2) max was 59±5.5 ml/kg/min. Participants' mean weight reduction was 5.7±0.9 kg. There was an increase in plasma urea (11.6±2.6 to 15.8±3.8 mmol/L, p<0.001) and urine osmolarity (692±212 to 1094±140 mmol/kg, p<0.001) and a decrease in sodium levels (140.5±1.0 to 136.6±2.1 mmol/L, p<0.001) at the end of the study. Significant alterations in diastolic parameters included a decrease in mitral E wave (93.6 to 83.5 cm/s; p = 0.003), without change in E/A and E/E′ ratios, and an increase in iso-volumic relaxation time (73.9 to 82.9 ms, p = 0.006). There was no change in left or right ventricular systolic function, or pulmonary arterial pressure. Brain natriuretic peptide (BNP) levels were significantly reduced post-training (median 9 to 0 pg/ml, p<0.001). There was no elevation in Troponin T or CRP levels. On multivariate analysis, BNP reduction correlated with sodium levels and weight reduction (R = 0.8, p<0.001). CONCLUSIONS: Exposure to prolonged physical activity performed under caloric deprivation resulted in minor alterations of left ventricular diastolic function. BNP levels were significantly reduced due to negative water and sodium balance. |
format | Online Article Text |
id | pubmed-3286482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-32864822012-03-01 The Effect of Prolonged Physical Activity Performed during Extreme Caloric Deprivation on Cardiac Function Planer, David Leibowitz, David Hadid, Amir Erlich, Tomer Sharon, Nir Paltiel, Ora Jacoby, Elad Lotan, Chaim Moran, Daniel S. PLoS One Research Article BACKGROUND: Endurance exercise may induce transient cardiac dysfunction. Data regarding the effect of caloric restriction on cardiac function is limited. We studied the effect of physical activity performed during extreme caloric deprivation on cardiac function. METHODS: Thirty-nine healthy male soldiers (mean age 20±0.3 years) were studied during a field training exercise lasted 85–103 hours, with negligible food intake and unlimited water supply. Anthropometric measurements, echocardiographic examinations and blood and urine tests were performed before and after the training exercise. RESULTS: Baseline VO(2) max was 59±5.5 ml/kg/min. Participants' mean weight reduction was 5.7±0.9 kg. There was an increase in plasma urea (11.6±2.6 to 15.8±3.8 mmol/L, p<0.001) and urine osmolarity (692±212 to 1094±140 mmol/kg, p<0.001) and a decrease in sodium levels (140.5±1.0 to 136.6±2.1 mmol/L, p<0.001) at the end of the study. Significant alterations in diastolic parameters included a decrease in mitral E wave (93.6 to 83.5 cm/s; p = 0.003), without change in E/A and E/E′ ratios, and an increase in iso-volumic relaxation time (73.9 to 82.9 ms, p = 0.006). There was no change in left or right ventricular systolic function, or pulmonary arterial pressure. Brain natriuretic peptide (BNP) levels were significantly reduced post-training (median 9 to 0 pg/ml, p<0.001). There was no elevation in Troponin T or CRP levels. On multivariate analysis, BNP reduction correlated with sodium levels and weight reduction (R = 0.8, p<0.001). CONCLUSIONS: Exposure to prolonged physical activity performed under caloric deprivation resulted in minor alterations of left ventricular diastolic function. BNP levels were significantly reduced due to negative water and sodium balance. Public Library of Science 2012-02-24 /pmc/articles/PMC3286482/ /pubmed/22384007 http://dx.doi.org/10.1371/journal.pone.0031266 Text en Planer et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Planer, David Leibowitz, David Hadid, Amir Erlich, Tomer Sharon, Nir Paltiel, Ora Jacoby, Elad Lotan, Chaim Moran, Daniel S. The Effect of Prolonged Physical Activity Performed during Extreme Caloric Deprivation on Cardiac Function |
title | The Effect of Prolonged Physical Activity Performed during Extreme Caloric Deprivation on Cardiac Function |
title_full | The Effect of Prolonged Physical Activity Performed during Extreme Caloric Deprivation on Cardiac Function |
title_fullStr | The Effect of Prolonged Physical Activity Performed during Extreme Caloric Deprivation on Cardiac Function |
title_full_unstemmed | The Effect of Prolonged Physical Activity Performed during Extreme Caloric Deprivation on Cardiac Function |
title_short | The Effect of Prolonged Physical Activity Performed during Extreme Caloric Deprivation on Cardiac Function |
title_sort | effect of prolonged physical activity performed during extreme caloric deprivation on cardiac function |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286482/ https://www.ncbi.nlm.nih.gov/pubmed/22384007 http://dx.doi.org/10.1371/journal.pone.0031266 |
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