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TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated

BACKGROUND: Degraded extracellular matrix can stimulate the innate immune system via the Toll-Like Receptor-4 (TLR4). In the pancreas, syndecan-anchored heparan sulphate (HS) on the ductal epithelium can be cleaved off its protein cores by the proteases (trypsin and elastase) and potentially activat...

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Detalles Bibliográficos
Autores principales:	Akbarshahi, Hamid, Axelsson, Jakob BF, Said, Katarzyna, Malmström, Anders, Fischer, Hans, Andersson, Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286488/ https://www.ncbi.nlm.nih.gov/pubmed/22188870 http://dx.doi.org/10.1186/1479-5876-9-219

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