Cargando…

Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response

Selective small-molecule inhibitors represent powerful tools for the dissection of complex biological processes. ES(I) (eeyarestatin I) is a novel modulator of ER (endoplasmic reticulum) function. In the present study, we show that in addition to acutely inhibiting ERAD (ER-associated degradation),...

Descripción completa

Detalles Bibliográficos
Autores principales:	McKibbin, Craig, Mares, Alina, Piacenti, Michela, Williams, Helen, Roboti, Peristera, Puumalainen, Marjo, Callan, Anna C., Lesiak-Mieczkowska, Karolina, Linder, Stig, Harant, Hanna, High, Stephen, Flitsch, Sabine L., Whitehead, Roger C., Swanton, Eileithyia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286858/ https://www.ncbi.nlm.nih.gov/pubmed/22145777 http://dx.doi.org/10.1042/BJ20111220

Ejemplares similares

Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases
por: Sun, Chao, et al.
Publicado: (2014)

Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca(2+) Leakage from the Endoplasmic Reticulum
por: Gamayun, Igor, et al.
Publicado: (2019)

Eeyarestatin 1 Interferes with Both Retrograde and Anterograde Intracellular Trafficking Pathways
por: Aletrari, Mina-Olga, et al.
Publicado: (2011)

Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex
por: Roboti, Peristera, et al.
Publicado: (2022)

Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis
por: Roboti, Peristera, et al.
Publicado: (2021)

OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation
por: Dumax-Vorzet, Audrey, et al.
Publicado: (2013)

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome
por: Lopez-Castejon, Gloria, et al.
Publicado: (2013)

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor
por: O’Keefe, Sarah, et al.
Publicado: (2021)

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor
por: O'Keefe, Sarah, et al.
Publicado: (2021)

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation
por: Zong, Guanghui, et al.
Publicado: (2019)

Eeyarestatin 24 impairs SecYEG‐dependent protein trafficking and inhibits growth of clinically relevant pathogens
por: Steenhuis, Maurice, et al.
Publicado: (2020)

Protein co-translocational unfolding depends on the direction of pulling
por: Rodriguez-Larrea, David, et al.
Publicado: (2014)

Structural determinants for protein unfolding and translocation by the Hsp104 protein disaggregase
por: Lee, Jungsoon, et al.
Publicado: (2017)

His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation
por: Parkinson, Gabrielle, et al.
Publicado: (2021)

Free-energy landscapes of membrane co-translocational protein unfolding
por: Rosen, Christian Bech, et al.
Publicado: (2020)

ERAD of proteins containing aberrant transmembrane domains requires ubiquitylation of cytoplasmic lysine residues
por: Briant, Kit, et al.
Publicado: (2015)

Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response
por: Larburu, Natacha, et al.
Publicado: (2020)

Dual Action of Eeyarestatin 24 on Sec-Dependent Protein Secretion and Bacterial DNA
por: Schäfer, Ann-Britt, et al.
Publicado: (2023)

The golgin GMAP-210 is required for efficient membrane trafficking in the early secretory pathway
por: Roboti, Peristera, et al.
Publicado: (2015)

Positional editing of transmembrane domains during ion channel assembly
por: Öjemalm, Karin, et al.
Publicado: (2013)

Unfolded Protein Responses With or Without Unfolded Proteins?
por: Snapp, Erik L.
Publicado: (2012)

Transmembrane domain quality control systems operate at the endoplasmic reticulum and Golgi apparatus
por: Briant, Kit, et al.
Publicado: (2017)

Coupling of vesicle tethering and Rab binding is required for in vivo functionality of the golgin GMAP-210
por: Sato, Keisuke, et al.
Publicado: (2015)

Vademecum del cuidador de Caballos/
por: McKibbin, Lloyd S.
Publicado: (1979)

A GWEP COLLABORATION: IMPLEMENTING THE AWV IN A RURAL PRIMARY CARE CLINIC
por: McKibbin, Christine
Publicado: (2019)

Decolonising Canadian water governance: lessons from Indigenous case studies
por: McKibbin, Corey
Publicado: (2023)

Translocation through the Conjugative Type IV Secretion System Requires Unfolding of Its Protein Substrate
por: Trokter, Martina, et al.
Publicado: (2018)

Protein Unfolding—Thermodynamic Perspectives and Unfolding Models
por: Seelig, Joachim, et al.
Publicado: (2023)

Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation
por: Miletic, Sean, et al.
Publicado: (2021)

Rare retinal complications of bone marrow transplantation (BMT): a case report
por: Butt, Farhat, et al.
Publicado: (2018)

THE POWER OF RURAL PARTNERSHIP: MEETING NEEDS AND FOSTERING INNOVATION THROUGH THE WYOMING GWEP
por: McKibbin, Christine, et al.
Publicado: (2022)

Coarse-Grained Simulations of Topology-Dependent Mechanisms of Protein Unfolding and Translocation Mediated by ClpY ATPase Nanomachines
por: Kravats, Andrea N., et al.
Publicado: (2016)

Slow Unfolding of Monomeric Proteins from Hyperthermophiles with Reversible Unfolding
por: Mukaiyama, Atsushi, et al.
Publicado: (2009)

Unfolding the Unfolded Protein Response: Unique Insights into Brain Ischemia
por: Sanderson, Thomas H., et al.
Publicado: (2015)

New Advances in Tissue Metabolomics: A Review
por: Saoi, Michelle, et al.
Publicado: (2021)

Containing the Damage of Unfolded Proteins
por: Gross, Liza
Publicado: (2006)

Melanoma and the Unfolded Protein Response
por: Sykes, Erin K., et al.
Publicado: (2016)

Natively unfolded proteins: An overview
por: Nishikawa, Ken
Publicado: (2009)

Unfolding the Mysteries of Protein Metamorphosis
por: Dishman, Acacia F., et al.
Publicado: (2018)

Unfolded Protein Response and Cancer
por: Wu, Lihua, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_90d4dqf6suimusdhbaqmo9pqp7