JAK2 Inhibition: Reviewing a New Therapeutical Option in Myeloproliferative Neoplasms

JAK2 is a tyrosine kinase gene that plays an essential role in the development of normal haematopoiesis. Hyperactivation of JAK2 occurs in myeloproliferative neoplasms by different mechanisms. As a consequence, JAK2 inhibitors have been designed to suppress the cytokine signalling cascade caused by...

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Detalles Bibliográficos
Autores principales: Bellido, Mar, te Boekhorst, Peter A. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286888/
https://www.ncbi.nlm.nih.gov/pubmed/22400031
http://dx.doi.org/10.1155/2012/535709

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