mRNA 3′ End Processing Factors: A Phylogenetic Comparison

Almost all eukaryotic mRNAs possess 3′ ends with a polyadenylate (poly(A)) tail. This poly(A) tail is not encoded in the genome but is added by the process of polyadenylation. Polyadenylation is a two-step process, and this process is accomplished by multisubunit protein factors. Here, we comprehens...

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Detalles Bibliográficos
Autores principales: Darmon, Sarah K., Lutz, Carol S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287031/
https://www.ncbi.nlm.nih.gov/pubmed/22400011
http://dx.doi.org/10.1155/2012/876893
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author Darmon, Sarah K.
Lutz, Carol S.
author_facet Darmon, Sarah K.
Lutz, Carol S.
author_sort Darmon, Sarah K.
collection PubMed
description Almost all eukaryotic mRNAs possess 3′ ends with a polyadenylate (poly(A)) tail. This poly(A) tail is not encoded in the genome but is added by the process of polyadenylation. Polyadenylation is a two-step process, and this process is accomplished by multisubunit protein factors. Here, we comprehensively compare the protein machinery responsible for polyadenylation of mRNAs across many evolutionary divergent species, and we have found these protein factors to be remarkably conserved in nature. These data suggest that polyadenylation of mRNAs is an ancient process.
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spelling pubmed-32870312012-03-07 mRNA 3′ End Processing Factors: A Phylogenetic Comparison Darmon, Sarah K. Lutz, Carol S. Comp Funct Genomics Research Article Almost all eukaryotic mRNAs possess 3′ ends with a polyadenylate (poly(A)) tail. This poly(A) tail is not encoded in the genome but is added by the process of polyadenylation. Polyadenylation is a two-step process, and this process is accomplished by multisubunit protein factors. Here, we comprehensively compare the protein machinery responsible for polyadenylation of mRNAs across many evolutionary divergent species, and we have found these protein factors to be remarkably conserved in nature. These data suggest that polyadenylation of mRNAs is an ancient process. Hindawi Publishing Corporation 2012 2012-02-06 /pmc/articles/PMC3287031/ /pubmed/22400011 http://dx.doi.org/10.1155/2012/876893 Text en Copyright © 2012 S. K. Darmon and C. S. Lutz. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Darmon, Sarah K.
Lutz, Carol S.
mRNA 3′ End Processing Factors: A Phylogenetic Comparison
title mRNA 3′ End Processing Factors: A Phylogenetic Comparison
title_full mRNA 3′ End Processing Factors: A Phylogenetic Comparison
title_fullStr mRNA 3′ End Processing Factors: A Phylogenetic Comparison
title_full_unstemmed mRNA 3′ End Processing Factors: A Phylogenetic Comparison
title_short mRNA 3′ End Processing Factors: A Phylogenetic Comparison
title_sort mrna 3′ end processing factors: a phylogenetic comparison
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287031/
https://www.ncbi.nlm.nih.gov/pubmed/22400011
http://dx.doi.org/10.1155/2012/876893
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