VEGF ameliorates the ataxic phenotype in spinocerebellar ataxia type 1 (SCA1) mice

SCA1 is an adult-onset, dominantly inherited neurodegenerative disease caused by expansion of a glutamine repeat tract in ATXN1. Although the precise function of ATXN1 remains elusive, it appears to play a role in transcriptional repression. We find that mutant ATXN1 suppresses transcription of the...

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Detalles Bibliográficos
Autores principales: Cvetanovic, Marija, Patel, Jay, Marti, Hugo H, Kini, Ameet R, Opal, Puneet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287040/
https://www.ncbi.nlm.nih.gov/pubmed/22001907
http://dx.doi.org/10.1038/nm.2494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287040/
https://www.ncbi.nlm.nih.gov/pubmed/22001907
http://dx.doi.org/10.1038/nm.2494

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