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VEGF ameliorates the ataxic phenotype in spinocerebellar ataxia type 1 (SCA1) mice
SCA1 is an adult-onset, dominantly inherited neurodegenerative disease caused by expansion of a glutamine repeat tract in ATXN1. Although the precise function of ATXN1 remains elusive, it appears to play a role in transcriptional repression. We find that mutant ATXN1 suppresses transcription of the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287040/ https://www.ncbi.nlm.nih.gov/pubmed/22001907 http://dx.doi.org/10.1038/nm.2494 |