Hsp90 depletion goes wild

Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laborat...

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Detalles Bibliográficos
Autores principales: Siegal, Mark L, Masel, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287126/
https://www.ncbi.nlm.nih.gov/pubmed/22369621
http://dx.doi.org/10.1186/1741-7007-10-14
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author Siegal, Mark L
Masel, Joanna
author_facet Siegal, Mark L
Masel, Joanna
author_sort Siegal, Mark L
collection PubMed
description Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation. See research article http://wwww.biomedcentral.com/1471-2148/12/25
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spelling pubmed-32871262012-02-28 Hsp90 depletion goes wild Siegal, Mark L Masel, Joanna BMC Biol Commentary Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation. See research article http://wwww.biomedcentral.com/1471-2148/12/25 BioMed Central 2012-02-27 /pmc/articles/PMC3287126/ /pubmed/22369621 http://dx.doi.org/10.1186/1741-7007-10-14 Text en Copyright ©2012 Siegal and Masel; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Siegal, Mark L
Masel, Joanna
Hsp90 depletion goes wild
title Hsp90 depletion goes wild
title_full Hsp90 depletion goes wild
title_fullStr Hsp90 depletion goes wild
title_full_unstemmed Hsp90 depletion goes wild
title_short Hsp90 depletion goes wild
title_sort hsp90 depletion goes wild
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287126/
https://www.ncbi.nlm.nih.gov/pubmed/22369621
http://dx.doi.org/10.1186/1741-7007-10-14
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