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Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing

DNA methylation is the most common form of DNA modification in prokaryotic and eukaryotic genomes. We have applied the method of single-molecule, real-time (SMRT®) DNA sequencing that is capable of direct detection of modified bases at single-nucleotide resolution to characterize the specificity of...

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Detalles Bibliográficos
Autores principales:	Clark, Tyson A., Murray, Iain A., Morgan, Richard D., Kislyuk, Andrey O., Spittle, Kristi E., Boitano, Matthew, Fomenkov, Alexey, Roberts, Richard J., Korlach, Jonas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287169/ https://www.ncbi.nlm.nih.gov/pubmed/22156058 http://dx.doi.org/10.1093/nar/gkr1146

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