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XRCC4's interaction with XLF is required for coding (but not signal) end joining

XRCC4 and XLF are structurally related proteins important for DNA Ligase IV function. XRCC4 forms a tight complex with DNA Ligase IV while XLF interacts directly with XRCC4. Both XRCC4 and XLF form homodimers that can polymerize as heterotypic filaments independently of DNA Ligase IV. Emerging struc...

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Detalles Bibliográficos
Autores principales:	Roy, Sunetra, Andres, Sara N., Vergnes, Alexandra, Neal, Jessica A., Xu, Yao, Yu, Yaping, Lees-Miller, Susan P., Junop, Murray, Modesti, Mauro, Meek, Katheryn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287172/ https://www.ncbi.nlm.nih.gov/pubmed/22228831 http://dx.doi.org/10.1093/nar/gkr1315

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