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A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro

SP1 is a ubiquitous transcription factor that is involved in the regulation of various house-keeping genes. It is known that it acts by binding to a double-stranded consensus motif. Here, we have discovered that SP1 binds also to a non-canonical DNA structure, a G-quadruplex, with high affinity. In...

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Detalles Bibliográficos
Autores principales:	Raiber, Eun-Ang, Kranaster, Ramon, Lam, Enid, Nikan, Mehran, Balasubramanian, Shankar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287196/ https://www.ncbi.nlm.nih.gov/pubmed/22021377 http://dx.doi.org/10.1093/nar/gkr882

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