Strand antagonism in RNAi: an explanation of differences in potency between intracellularly expressed siRNA and shRNA

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Strategies to regulate gene function frequently use small interfering RNAs (siRNAs) that can be made from their shRNA precursors via Dicer. However, when the duplex components of these siRNA effectors are expressed from their respective coding genes, the RNA interference (RNAi) activity is much redu...

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Detalles Bibliográficos
Autores principales: Jin, Xin, Sun, Tingting, Zhao, Chuanke, Zheng, Yongxiang, Zhang, Yufan, Cai, Weijing, He, Qiuchen, Taira, Kaz, Zhang, Lihe, Zhou, Demin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287203/
https://www.ncbi.nlm.nih.gov/pubmed/22039150
http://dx.doi.org/10.1093/nar/gkr927
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