Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2

Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset autosomal dominant Parkinson’s disease. We employed a novel, parallel, compound-centric approach to identify a potent and selective LRRK2 inhibitor LRRK2-IN-1, and demonstrated that inhibition of LRRK2 induces...

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Detalles Bibliográficos
Autores principales: Deng, Xianming, Dzamko, Nicolas, Prescott, Alan, Davies, Paul, Liu, Qingsong, Yang, Qingkai, Lee, Jiing-Dwan, Patricelli, Matthew P., Nomanbhoy, Tyzoon K., Alessi, Dario R., Gray, Nathanael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287420/
https://www.ncbi.nlm.nih.gov/pubmed/21378983
http://dx.doi.org/10.1038/nchembio.538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287420/
https://www.ncbi.nlm.nih.gov/pubmed/21378983
http://dx.doi.org/10.1038/nchembio.538

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