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Novel Markov model of induced pluripotency predicts gene expression changes in reprogramming
BACKGROUND: Somatic cells can be reprogrammed to induced-pluripotent stem cells (iPSCs) by introducing few reprogramming factors, which challenges the long held view that cell differentiation is irreversible. However, the mechanism of induced pluripotency is still unknown. METHODS: Inspired by the p...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287488/ https://www.ncbi.nlm.nih.gov/pubmed/22784579 http://dx.doi.org/10.1186/1752-0509-5-S2-S8 |