Cargando…

Maximizing biomarker discovery by minimizing gene signatures

BACKGROUND: The use of gene signatures can potentially be of considerable value in the field of clinical diagnosis. However, gene signatures defined with different methods can be quite various even when applied the same disease and the same endpoint. Previous studies have shown that the correct sele...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Chang, Wang, Junwei, Zhao, Chen, Fostel, Jennifer, Tong, Weida, Bushel, Pierre R, Deng, Youping, Pusztai, Lajos, Symmans, W Fraser, Shi, Tieliu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287502/ https://www.ncbi.nlm.nih.gov/pubmed/22369133 http://dx.doi.org/10.1186/1471-2164-12-S5-S6

Ejemplares similares

Maximum predictive power of the microarray-based models for clinical outcomes is limited by correlation between endpoint and gene expression profile
por: Zhao, Chen, et al.
Publicado: (2011)

The Bimodality Index: A Criterion for Discovering and Ranking Bimodal Signatures from Cancer Gene Expression Profiling Data
por: Wang, Jing, et al.
Publicado: (2009)

Editorial: Integrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects With Genomic Sciences
por: Bushel, Pierre R., et al.
Publicado: (2018)

Lack of sufficiently strong informative features limits the potential of gene expression analysis as predictive tool for many clinical classification problems
por: Hess, Kenneth R, et al.
Publicado: (2011)

Reproducibility of Variant Calls in Replicate Next Generation Sequencing Experiments
por: Qi, Yuan, et al.
Publicado: (2015)

Proceedings of the First International Conference on Toxicogenomics Integrated with Environmental Sciences (TIES-2007)
por: Bushel, Pierre R, et al.
Publicado: (2009)

Predicting prognosis of breast cancer with gene signatures: are we lost in a sea of data?
por: Iwamoto, Takayuki, et al.
Publicado: (2010)

Promises and caveats of in silico biomarker discovery
por: Pusztai, L, et al.
Publicado: (2008)

Targeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples
por: Fu, Chunxiao, et al.
Publicado: (2021)

Evaluation of biological pathways involved in chemotherapy response in breast cancer
por: Tordai, Attila, et al.
Publicado: (2008)

Centromere protein-A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor-positive breast cancer
por: McGovern, Susan L, et al.
Publicado: (2012)

A Systematic Evaluation of Multi-Gene Predictors for the Pathological Response of Breast Cancer Patients to Chemotherapy
por: Shen, Kui, et al.
Publicado: (2012)

Minimal cells, maximal knowledge
por: Lachance, Jean-Christophe, et al.
Publicado: (2019)

Characterization of DNA variants in the human kinome in breast cancer
por: Agarwal, Divyansh, et al.
Publicado: (2015)

Bone metastasis-related signaling pathways in breast cancers stratified by estrogen receptor status
por: Hayashi, Naoki, et al.
Publicado: (2017)

The impact of RNA extraction method on accurate RNA sequencing from formalin-fixed paraffin-embedded tissues
por: Marczyk, Michal, et al.
Publicado: (2019)

Five-Feature Model for Developing the Classifier for Synergistic vs. Antagonistic Drug Combinations Built by XGBoost
por: Ji, Xiangjun, et al.
Publicado: (2019)

Discovery of Urinary Proteomic Signature for Differential Diagnosis of Acute Appendicitis
por: Zhao, Yinghua, et al.
Publicado: (2020)

CD40 signaling predicts response to preoperative trastuzumab and concomitant paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide in HER-2-overexpressing breast cancer
por: Esteva, Francisco J, et al.
Publicado: (2007)

Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response
por: Li, Qiyuan, et al.
Publicado: (2011)

Maximizing binary interactome mapping with a minimal number of assays
por: Choi, Soon Gang, et al.
Publicado: (2019)

Gene expression profiling of breast cancer
por: Pusztai, Lajos
Publicado: (2009)

Minimally invasive surgery - maximal exposure to research
por: Matteotti, Ronald, et al.
Publicado: (2011)

Dynamic classification using case-specific training cohorts outperforms static gene expression signatures in breast cancer
por: Győrffy, Balázs, et al.
Publicado: (2015)

Editorial: Advancing Genomics for Rare Disease Diagnosis and Therapy Development
por: Liu, Zhichao, et al.
Publicado: (2020)

Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics
por: Zeng, Li, et al.
Publicado: (2021)

A transcriptional dynamic network during Arabidopsis thaliana pollen development
por: Wang, Jigang, et al.
Publicado: (2011)

Nucleosome structure incorporated histone acetylation site prediction in arabidopsis thaliana
por: Zhao, Chen, et al.
Publicado: (2010)

Biomarker Gene Signature Discovery Integrating Network Knowledge
por: Cun, Yupeng, et al.
Publicado: (2012)

Discovery of a maximally charged Weyl point
por: Chen, Qiaolu, et al.
Publicado: (2022)

Combination therapy design for maximizing sensitivity and minimizing toxicity
por: Matlock, Kevin, et al.
Publicado: (2017)

Outbreak minimization v.s. influence maximization: an optimization framework
por: Cheng, Chun-Hung, et al.
Publicado: (2020)

Spatiotemporal dynamics of maximal and minimal EEG spectral power
por: Menceloglu, Melisa, et al.
Publicado: (2021)

Simple combination of multiple somatic variant callers to increase accuracy
por: Trevarton, Alexander J., et al.
Publicado: (2023)

Cell Line Derived Multi-Gene Predictor of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer: A Validation Study on US Oncology 02-103 Clinical Trial
por: Shen, Kui, et al.
Publicado: (2012)

Cystoscopic findings in women with minimal and maximal lower urinary tract symptoms
por: Marcu, Ioana, et al.
Publicado: (2021)

Minimal Residual Disease Assessment in Multiple Myeloma Patients: Minimal Disease With Maximal Implications
por: Charalampous, Charalampos, et al.
Publicado: (2022)

Dissecting the Characteristics and Dynamics of Human Protein Complexes at Transcriptome Cascade Using RNA-Seq Data
por: Chen, Geng, et al.
Publicado: (2013)

Molecular profiling contributes more than routine histology and immonohistochemistry to breast cancer diagnostics
por: Shiang, Christine, et al.
Publicado: (2010)

Mapping knowledge landscapes and emerging trends of the biomarkers in melanoma: a bibliometric analysis from 2004 to 2022
por: Wan, Yantong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rboapsmp1jrro1k4567223uu33