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Effects of genome-wide copy number variation on expression in mammalian cells

BACKGROUND: There is only a limited understanding of the relation between copy number and expression for mammalian genes. We fine mapped cis and trans regulatory loci due to copy number change for essentially all genes using a human-hamster radiation hybrid (RH) panel. These loci are called copy num...

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Detalles Bibliográficos
Autores principales: Wang, Richard T, Ahn, Sangtae, Park, Christopher C, Khan, Arshad H, Lange, Kenneth, Smith, Desmond J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287593/
https://www.ncbi.nlm.nih.gov/pubmed/22085887
http://dx.doi.org/10.1186/1471-2164-12-562