Cargando…

Stratify or adjust? Dealing with multiple populations when evaluating rare variants

The unrelated individuals sample from Genetic Analysis Workshop 17 consists of a small number of subjects from eight population samples and genetic data composed mostly of rare variants. We compare two simple approaches to collapsing rare variants within genes for their utility in identifying genes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Culverhouse, Robert C, Hinrichs, Anthony L, Suarez, Brian K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287824/ https://www.ncbi.nlm.nih.gov/pubmed/22373399 http://dx.doi.org/10.1186/1753-6561-5-S9-S101

Ejemplares similares

Identifying cryptic population structure in multigenerational pedigrees in a Mexican American sample
por: Culverhouse, Robert C, et al.
Publicado: (2014)

Detecting population stratification using related individuals
por: Hinrichs, Anthony L, et al.
Publicado: (2009)

Linkage analysis merging replicate phenotypes: an application to three quantitative phenotypes in two African samples
por: Hinrichs, Anthony L, et al.
Publicado: (2011)

Genotypic discrepancies arising from imputation
por: Hinrichs, Anthony L, et al.
Publicado: (2014)

Linkage, case-control association, and family-based association tests for complex disorders
por: Suarez, Brian K, et al.
Publicado: (2007)

Gene × gene and gene × environment interactions for complex disorders
por: Culverhouse, Robert, et al.
Publicado: (2007)

Linkage and association analyses of principal components in expression data
por: Hinrichs, Anthony L, et al.
Publicado: (2007)

A search for non-chromosome 6 susceptibility loci contributing to rheumatoid arthritis
por: Suarez, Brian K, et al.
Publicado: (2009)

Power and false-positive rates for the restricted partition method (RPM) in a large candidate gene data set
por: Culverhouse, Robert, et al.
Publicado: (2009)

Identifying rare variants from exome scans: the GAW17 experience
por: Ghosh, Saurabh, et al.
Publicado: (2011)

Methods for adjusting population structure and familial relatedness in association test for collective effect of multiple rare variants on quantitative traits
por: Zhang, Qunyuan, et al.
Publicado: (2011)

Adjustment of familial relatedness in association test for rare variants
por: Li, Cong, et al.
Publicado: (2014)

Different approaches for dealing with rare variants in family-based genetic studies: application of a Genetic Analysis Workshop 17 problem
por: Alfonso de Almeida, Marcio Augusto, et al.
Publicado: (2011)

Are there mappable genes for family resemblance for the magnitude of intra-individual variation in systolic blood pressure?
por: Lin, Jennifer, et al.
Publicado: (2003)

Identification of multiple rare variants associated with a disease
por: Jung, Jeesun, et al.
Publicado: (2011)

The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure
por: Kauwe, John SK, et al.
Publicado: (2005)

Rare variant density across the genome and across populations
por: Raska, Paola, et al.
Publicado: (2011)

Evaluation of pooled association tests for rare variant identification
por: Lin, Wan-Yu, et al.
Publicado: (2011)

Evaluating methods for the analysis of rare variants in sequence data
por: Luedtke, Alexander, et al.
Publicado: (2011)

Population structure analysis using rare and common functional variants
por: Baye, Tesfaye M, et al.
Publicado: (2011)

Adjusting for population stratification and relatedness with sequencing data
por: Zhang, Yiwei, et al.
Publicado: (2014)

Methods to evaluate rare variants gene-age interaction for triglycerides
por: Gao, Tony Huayang, et al.
Publicado: (2018)

Family- and population-based designs identify different rare causal variants
por: Zhang, Xue, et al.
Publicado: (2011)

Identifying rare variant associations in population-based and family-based designs
por: Turkmen, Asuman S, et al.
Publicado: (2014)

Evaluation of the power and type I error of recently proposed family-based tests of association for rare variants
por: Hainline, Allison, et al.
Publicado: (2014)

Dealing with missing phase and missing data in phylogeny-based analysis
por: Bardel, Claire, et al.
Publicado: (2007)

Effect of population stratification analysis on false-positive rates for common and rare variants
por: He, Hua, et al.
Publicado: (2011)

Association screening for genes with multiple potentially rare variants: an inverse-probability weighted clustering approach
por: Liu, Ying, et al.
Publicado: (2011)

Application of family-based tests of association for rare variants to pathways
por: Greco, Brian, et al.
Publicado: (2014)

Multipoint identity-by-descent computations for single-point polymorphism and microsatellite maps
por: Hinrichs, Anthony L, et al.
Publicado: (2005)

Modeling of multivariate longitudinal phenotypes in family genetic studies with Bayesian multiplicity adjustment
por: Ding, Lili, et al.
Publicado: (2014)

Do rare variant genotypes predict common variant genotypes?
por: Kent, Jack W, et al.
Publicado: (2011)

Evaluating methods for combining rare variant data in pathway-based tests of genetic association
por: Petersen, Ashley, et al.
Publicado: (2011)

Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures
por: Dunn, Gerald, et al.
Publicado: (2005)

Progress in methods for rare variant association
por: Santorico, Stephanie A., et al.
Publicado: (2016)

Age-Stratified QTL Genome Scan Analyses for Anthropometric Measures
por: Beck, Stephanie R, et al.
Publicado: (2003)

Age-stratified heritability estimation in the Framingham Heart Study families
por: Brown, W Mark, et al.
Publicado: (2003)

Use of principal components to aggregate rare variants in case-control and family-based association studies in the presence of multiple covariates
por: Kazma, Rémi, et al.
Publicado: (2011)

Disease risk prediction with rare and common variants
por: Wu, Chengqing, et al.
Publicado: (2011)

Capability of common SNPs to tag rare variants
por: Sun, Xiangqing, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ctqm7bv4t5b8s3sm8p1fo7shp7