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Detection of rare variant effects in association studies: extreme values, iterative regression, and a hybrid approach
We develop statistical methods for detecting rare variants that are associated with quantitative traits. We propose two strategies and their combination for this purpose: the iterative regression strategy and the extreme values strategy. In the iterative regression strategy, we use iterative regress...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287836/ https://www.ncbi.nlm.nih.gov/pubmed/22373188 http://dx.doi.org/10.1186/1753-6561-5-S9-S112 |