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Identification of genes associated with complex traits by testing the genetic dissimilarity between individuals
Using the exome sequencing data from 697 unrelated individuals and their simulated disease phenotypes from Genetic Analysis Workshop 17, we develop and apply a gene-based method to identify the relationship between a gene with multiple rare genetic variants and a phenotype. The method is based on th...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287845/ https://www.ncbi.nlm.nih.gov/pubmed/22373401 http://dx.doi.org/10.1186/1753-6561-5-S9-S120 |