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Use of principal components to aggregate rare variants in case-control and family-based association studies in the presence of multiple covariates
Rare variants may help to explain some of the missing heritability of complex diseases. Technological advances in next-generation sequencing give us the opportunity to test this hypothesis. We propose two new methods (one for case-control studies and one for family-based studies) that combine aggreg...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287864/ https://www.ncbi.nlm.nih.gov/pubmed/22373382 http://dx.doi.org/10.1186/1753-6561-5-S9-S29 |